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Hepatitis E Virus Assembly and Release
Open AccessReview

The Interplay between Host Innate Immunity and Hepatitis E Virus

by Yang Li 1,2, Changbo Qu 2, Peifa Yu 2, Xumin Ou 2, Qiuwei Pan 1,2,* and Wenshi Wang 2,3,*
China-Malaysia National Joint Laboratory, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China
Postgraduate School Molecular Medicine, Erasmus MC-University Medical Center, 3015 CN Rotterdam, The Netherlands
Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany
Authors to whom correspondence should be addressed.
Viruses 2019, 11(6), 541;
Received: 19 April 2019 / Revised: 24 May 2019 / Accepted: 6 June 2019 / Published: 11 June 2019
(This article belongs to the Special Issue Hepatitis E Virus)
Hepatitis E virus (HEV) infection represents an emerging global health issue, whereas the clinical outcomes vary dramatically among different populations. The host innate immune system provides a first-line defense against the infection, but dysregulation may partially contribute to severe pathogenesis. A growing body of evidence has indicated the active response of the host innate immunity to HEV infection both in experimental models and in patients. In turn, HEV has developed sophisticated strategies to counteract the host immune system. In this review, we aim to comprehensively decipher the processes of pathogen recognition, interferon, and inflammatory responses, and the involvement of innate immune cells in HEV infection. We further discuss their implications in understanding the pathogenic mechanisms and developing antiviral therapies. View Full-Text
Keywords: Innate immunity; Hepatitis E virus; Interferon; Inflammation Innate immunity; Hepatitis E virus; Interferon; Inflammation
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Li, Y.; Qu, C.; Yu, P.; Ou, X.; Pan, Q.; Wang, W. The Interplay between Host Innate Immunity and Hepatitis E Virus. Viruses 2019, 11, 541.

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