Next Article in Journal
Structure and Hierarchy of Influenza Virus Models Revealed by Reaction Network Analysis
Previous Article in Journal
Post-Epidemic Distribution of Schmallenberg Virus in Culicoides Arbovirus Vectors in Poland
Previous Article in Special Issue
Mosquito Small RNA Responses to West Nile and Insect-Specific Virus Infections in Aedes and Culex Mosquito Cells
Article Menu

Export Article

Open AccessReview

Antiviral RNAi in Insects and Mammals: Parallels and Differences

Department of Medical Microbiology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(5), 448; https://doi.org/10.3390/v11050448
Received: 16 April 2019 / Revised: 14 May 2019 / Accepted: 15 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Transmission Dynamics of Insect Viruses)
  |  
PDF [3103 KB, uploaded 16 May 2019]
  |  

Abstract

The RNA interference (RNAi) pathway is a potent antiviral defense mechanism in plants and invertebrates, in response to which viruses evolved suppressors of RNAi. In mammals, the first line of defense is mediated by the type I interferon system (IFN); however, the degree to which RNAi contributes to antiviral defense is still not completely understood. Recent work suggests that antiviral RNAi is active in undifferentiated stem cells and that antiviral RNAi can be uncovered in differentiated cells in which the IFN system is inactive or in infections with viruses lacking putative viral suppressors of RNAi. In this review, we describe the mechanism of RNAi and its antiviral functions in insects and mammals. We draw parallels and highlight differences between (antiviral) RNAi in these classes of animals and discuss open questions for future research. View Full-Text
Keywords: small interfering RNA; RNA interference; RNA virus; antiviral defense; innate immunity; interferon; stem cells small interfering RNA; RNA interference; RNA virus; antiviral defense; innate immunity; interferon; stem cells
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Schuster, S.; Miesen, P.; van Rij, R.P. Antiviral RNAi in Insects and Mammals: Parallels and Differences. Viruses 2019, 11, 448.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top