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Viruses 2018, 10(6), 314; https://doi.org/10.3390/v10060314

Understanding Oxidative Stress in Aedes during Chikungunya and Dengue Virus Infections Using Integromics Analysis

1
Vector Borne Diseases, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India
2
Transcriptional Regulation, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India
*
Authors to whom correspondence should be addressed.
Received: 28 February 2018 / Revised: 26 April 2018 / Accepted: 27 April 2018 / Published: 9 June 2018
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Abstract

Arboviral infection causes dysregulation of cascade of events involving numerous biomolecules affecting fitness of mosquito to combat virus. In response of the viral infection mosquito’s defense mechanism get initiated. Oxidative stress is among the first host responses triggered by the vector. Significant number of information is available showing changes in the transcripts and/or proteins upon Chikungunya virus and Dengue virus mono-infections and as co-infections. In the present study, we collected different -omics data available in the public database along with the data generated in our laboratory related to mono-infections or co-infections of these viruses. We analyzed the data and classified them into their respective pathways to study the role of oxidative stress in combating arboviral infection in Aedes mosquito. The analysis revealed that the oxidative stress related pathways functions in harmonized manner. View Full-Text
Keywords: Aedes; Arbovirus; chikungunya; dengue; proteomics; transcriptomics; metabolomics; oxidative stress Aedes; Arbovirus; chikungunya; dengue; proteomics; transcriptomics; metabolomics; oxidative stress
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Shrinet, J.; Bhavesh, N.S.; Sunil, S. Understanding Oxidative Stress in Aedes during Chikungunya and Dengue Virus Infections Using Integromics Analysis. Viruses 2018, 10, 314.

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