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Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam

Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX3 7FZ, UK
Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), 69365 Lyon CEDEX 07, France
The London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK
Author to whom correspondence should be addressed.
On behalf of the VIZIONS consortium.
Viruses 2018, 10(3), 102;
Received: 20 January 2018 / Revised: 19 February 2018 / Accepted: 23 February 2018 / Published: 28 February 2018
(This article belongs to the Section Animal Viruses)
Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined. View Full-Text
Keywords: rodents; bats; pegiviruses; hepatitis viruses; homologues; Vietnam rodents; bats; pegiviruses; hepatitis viruses; homologues; Vietnam
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Van Nguyen, D.; Van Nguyen, C.; Bonsall, D.; Ngo, T.T.; Carrique-Mas, J.; Pham, A.H.; Bryant, J.E.; Thwaites, G.; Baker, S.; Woolhouse, M.; Simmonds, P. Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam. Viruses 2018, 10, 102.

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