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Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases
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RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution

1
Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India
2
Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurgaon 122413, India
3
ICAR National Research Centre for Banana, Thayanur Post, Tiruchirapalli 620102, India
*
Authors to whom correspondence should be addressed.
Viruses 2018, 10(2), 76; https://doi.org/10.3390/v10020076
Received: 27 November 2017 / Revised: 30 January 2018 / Accepted: 3 February 2018 / Published: 10 February 2018
(This article belongs to the Special Issue Structure-Function Relationships in Viral Polymerases)
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA viruses that is indispensable for replicating the genome as well as for carrying out transcription. The core structural features of RdRps are conserved, despite the divergence in their sequences. The structure of RdRp resembles that of a cupped right hand and consists of fingers, palm and thumb subdomains. The catalysis involves the participation of conserved aspartates and divalent metal ions. Complexes of RdRps with substrates, inhibitors and metal ions provide a comprehensive view of their functional mechanism and offer valuable insights regarding the development of antivirals. In this article, we provide an overview of the structural aspects of RdRps and their complexes from the Group III, IV and V viruses and their structure-based phylogeny. View Full-Text
Keywords: RNA viruses; RNA-dependent RNA polymerase; domains; motifs; structure-based Phylogeny; inhibitor complexes RNA viruses; RNA-dependent RNA polymerase; domains; motifs; structure-based Phylogeny; inhibitor complexes
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Venkataraman, S.; Prasad, B.V.L.S.; Selvarajan, R. RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution. Viruses 2018, 10, 76.

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