Next Article in Journal
Applications of Ni3Al Based Intermetallic Alloys—Current Stage and Potential Perceptivities
Next Article in Special Issue
Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation
Previous Article in Journal
Synthesis and Thermoelectric Properties in the 2D Ti1 xNbxS3 Trichalcogenides
Previous Article in Special Issue
Fibrin Hydrogel Based Bone Substitute Tethered with BMP-2 and BMP-2/7 Heterodimers
Open AccessArticle

A Novel Porcine Graft for Regeneration of Bone Defects

1
School of Dentistry, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan
2
School of Dental Technology, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan
3
Graduate Institute of Biomedical Materials & Tissue Engineering, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan
4
Dental Department of Taipei Medical University, Shuang-Ho Hospital, Taipei 110, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Franz E. Weber
Materials 2015, 8(5), 2523-2536; https://doi.org/10.3390/ma8052523
Received: 31 March 2015 / Revised: 23 April 2015 / Accepted: 29 April 2015 / Published: 12 May 2015
(This article belongs to the Special Issue Novel Bone Substitute Materials)
Bone regeneration procedures require alternative graft biomaterials to those for autogenous bone. Therefore, we developed a novel porcine graft using particle sizes of 250–500 μm and 500–1000 μm in rabbit calvarial bone defects and compared the graft properties with those of commercial hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) over eight weeks. Surgery was performed in 20 adult male New Zealand white rabbits. During a standardized surgical procedure, four calvarial critical-size defects of 5 mm diameter and 3 mm depth were prepared. The defects were filled with HA/β-TCP, 250–500 μm or 500–1000 μm porcine graft, and control defects were not filled. The animals were grouped for sacrifice at 1, 2, 4, and 8 weeks post-surgery. Subsequently, sample blocks were prepared for micro-computed tomography (micro-CT) scanning and histological sectioning. Similar bone formations were observed in all three treatment groups, although the 250–500 μm porcine graft performed slightly better. Rabbit calvarial bone tissue positively responded to porcine grafts and commercial HA/β-TCP, structural analyses showed similar crystallinity and porosity of the porcine and HA/β-TCP grafts, which facilitated bone formation through osteoconduction. These porcine grafts can be considered as graft substitutes, although further development is required for clinical applications. View Full-Text
Keywords: bone regeneration; bone graft; porcine tissue; in vivo test; hydroxyapatite bone regeneration; bone graft; porcine tissue; in vivo test; hydroxyapatite
Show Figures

Figure 1

MDPI and ACS Style

Salamanca, E.; Lee, W.-F.; Lin, C.-Y.; Huang, H.-M.; Lin, C.-T.; Feng, S.-W.; Chang, W.-J. A Novel Porcine Graft for Regeneration of Bone Defects. Materials 2015, 8, 2523-2536.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop