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Cellular Response to Doping of High Porosity Foamed Alumina with Ca, P, Mg, and Si

Biomedical Engineering, School of AMME J07, University of Sydney, Sydney, NSW 2006, Australia
Author to whom correspondence should be addressed.
Academic Editor: Juergen Stampfl
Materials 2015, 8(3), 1074-1088;
Received: 28 December 2014 / Revised: 28 February 2015 / Accepted: 5 March 2015 / Published: 13 March 2015
(This article belongs to the Special Issue Bioceramics)
PDF [1587 KB, uploaded 13 March 2015]


Foamed alumina was previously synthesised by direct foaming of sulphate salt blends varying ammonium mole fraction (AMF), foaming heating rate and sintering temperature. The optimal product was produced with 0.33AMF, foaming at 100 °C/h and sintering at 1600 °C. This product attained high porosity of 94.39%, large average pore size of 300 µm and the highest compressive strength of 384 kPa. To improve bioactivity, doping of porous alumina by soaking in dilute or saturated solutions of Ca, P, Mg, CaP or CaP + Mg was done. Saturated solutions of Ca, P, Mg, CaP and CaP + Mg were made with excess salt in distilled water and decanted. Dilute solutions were made by diluting the 100% solution to 10% concentration. Doping with Si was done using the sol gel method at 100% concentration only. Cell culture was carried out with MG63 osteosarcoma cells. Cellular response to the Si and P doped samples was positive with high cell populations and cell layer formation. The impact of doping with phosphate produced a result not previously reported. The cellular response showed that both Si and P doping improved the biocompatibility of the foamed alumina. View Full-Text
Keywords: foaming; porous alumina; doping; cellular response foaming; porous alumina; doping; cellular response

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MDPI and ACS Style

Soh, E.; Kolos, E.; Ruys, A.J. Cellular Response to Doping of High Porosity Foamed Alumina with Ca, P, Mg, and Si. Materials 2015, 8, 1074-1088.

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