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Open AccessArticle

In situ Surface Tailoring with Zwitterionic Carboxybetaine Moieties on Self-Assembled Thin Film for Antifouling Biointerfaces

by Chun-Jen Huang 1,2,* and Ying-Chih Chang 3,*
1
Graduate Institute of Biomedical Engineering, National Central University, Jhong-Li, Taoyuan 320, Taiwan
2
Department of Chemical and Material Engineering, National Central University, Jhong-Li, Taoyuan 320, Taiwan
3
Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
*
Authors to whom correspondence should be addressed.
Materials 2014, 7(1), 130-142; https://doi.org/10.3390/ma7010130
Received: 16 September 2013 / Revised: 12 November 2013 / Accepted: 20 December 2013 / Published: 27 December 2013
(This article belongs to the Special Issue Biocompatibility of Materials 2013)
A novel biointerface bearing zwitterionic carboxybetaine moieties was developed for effective resistance to nonspecific adsorption of proteins and blood cells. Self-assembled thin films (SAFs) of (N,N-dimethylaminopropyl) trimethoxysilane were formed as mattress layers by either vapor or solution deposition. Subsequently, the tertiary amine head groups on SAFs were reacted with β-propiolactone to give zwitterionic carboxybetaine moieties via in situ synthesis. The optimal reaction time of 8 h for both preparation methods was verified by static contact angle measurements. According to the X-ray photoelectron spectroscopy, 67.3% of amine groups on SAFs prepared from the vapor deposition was converted to the zwitterionic structures after reaction of β-propiolactone. The antifouling properties of the zwitterionic biointerfaces were quantitatively evaluated in the presence of protein solutions using a quartz crystal microbalance with dissipation, showing a great improvement by factors of 6.5 and 20.2 from tertiary amine SAFs and bare SiO2 surfaces, respectively. More importantly, the zwitterionic SAFs were brought to contact with undiluted human blood in chaotic-mixer microfluidic systems; the results present their capability to effectively repel blood cell adhesion. Accordingly, in this work, development of carboxybetaine SAFs offers a facile yet effective strategy to fabricate biocompatible biointerfaces for a variety of potential applications in surface coatings for medical devices. View Full-Text
Keywords: surface modification; zwitterionic materials; antifouling properties; self-assembled thin film; biocompatibility surface modification; zwitterionic materials; antifouling properties; self-assembled thin film; biocompatibility
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MDPI and ACS Style

Huang, C.-J.; Chang, Y.-C. In situ Surface Tailoring with Zwitterionic Carboxybetaine Moieties on Self-Assembled Thin Film for Antifouling Biointerfaces. Materials 2014, 7, 130-142.

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