This paper presents a study of hole quality and energy consumption in the process of drilling a thermoplastic polymeric material, polyether-ether-ketone, reinforced with 30% glass fibers (PEEK-GF30). PEEK-GF30’s capacity to be machined has focused on turning operations. Studies of drilling involving thermoplastic polymeric materials have considered materials with other types of matrices, or reinforcement. In this study, quantities such as maximum and mean surface roughness, delamination, maximum thrust force, maximum momentum, and energy required during the process were determined for three types of drill bits, and the most influential factors for each variable were identified using an ANOVA multifactor analysis. The highest quality and lowest energy consumption were achieved for a drill bit rotation speed of 7000 rpm and a feed rate of 400 mm/min with a tungsten carbide (WC) drill bit coated with titanium aluminum nitride (TiAlN). Although a WC drill bit with a diamond point reduces delamination, the roughness increases, thus, the choice of the drill bit type depends on the roughness allowed. A WC drill bit coated with TiAlN produces a good surface finish that can eliminate subsequent operations and requires less energy; thus, this type of drill bit is the most attractive of the types evaluated.