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Materials 2010, 3(5), 3204-3217;

A Brief Review of Chelators for Radiolabeling Oligomers

Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Author to whom correspondence should be addressed.
Received: 13 March 2010 / Revised: 26 March 2010 / Accepted: 10 May 2010 / Published: 14 May 2010
(This article belongs to the Special Issue Conjugated Oligomers)
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The chemical modification of oligomers such as DNA, PNA, MORF, LNA to attach radionuclides for nuclear imaging and radiotherapy applications has become a field rich in innovation as older methods are improved and new methods are introduced. This review intends to provide a brief overview of several chelators currently in use for the labeling of oligomers with metallic radionuclides such as 99mTc, 111In and 188Re. While DNA and its analogs have been radiolabeled with important radionuclides of nonmetals such as 32P, 35S, 14C, 18F and 125I, the labeling methods for these isotopes involve covalent chemistry that is quite distinct from the coordinate-covalent chelation chemistry described herein. In this review, we provide a summary of the several chelators that have been covalently conjugated to oligomers for the purpose of radiolabeling with metallic radionuclides by chelation and including details on the conjugation, the choice of radionuclides and labeling methods. View Full-Text
Keywords: oligomers; DNA analog; chelator; radionuclide oligomers; DNA analog; chelator; radionuclide

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Liu, Y.; Liu, G.; Hnatowich, D.J. A Brief Review of Chelators for Radiolabeling Oligomers. Materials 2010, 3, 3204-3217.

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