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Article

Biomimetic Ceramic Composite: Characterization, Cell Response, and In Vivo Biocompatibility

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Department of Dentistry, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City 242, Taiwan
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Division of Family and Operative Dentistry, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan
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School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
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Dental Department of Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
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Biomedical Technology R & D Center, China Medical University Hospital, Taichung 404, Taiwan
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Department of Oral Hygiene Care, Ching Kuo Institute of Management and Health, Keelung 203, Taiwan
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Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan
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Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, Japan
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3D Global Biotech Inc., New Taipei City 221, Taiwan
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Taiwan Society of Blood Biomaterials, New Taipei City 221, Taiwan
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Graduate Institute of Dental Science, College of Dentistry, China Medical University, Taichung 404, Taiwan
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School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
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Excelsior School, Arcadia, CA 91007, USA
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Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan
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Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan
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School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
*
Authors to whom correspondence should be addressed.
Co-first author: Yi-Jung Lu.
Academic Editors: Tobias Tauböck and Matej Par
Materials 2021, 14(23), 7374; https://doi.org/10.3390/ma14237374
Received: 15 October 2021 / Revised: 19 November 2021 / Accepted: 29 November 2021 / Published: 1 December 2021
(This article belongs to the Special Issue Bioactive Dental Materials)
The present study aimed to synthesize biphasic calcium phosphate ceramics (CaPs) composed of β-tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) from the propagated Scleractinian coral and dicalcium phosphate anhydrous using a solid-state reaction followed by heat treatment at a temperature of 1100 °C for 1 h to 7 days. The as-prepared coral and coral-derived biphasic CaPs samples were characterized through scanning electron microscopy, X-ray diffractometry, Fourier transform infrared spectroscopy, and Raman spectroscopy. The cell response of the biphasic CaPs was evaluated by in vitro cytotoxicity assessment using mouse fibroblast (L929) cells. The bilateral femoral defect rabbit model was used to assess the early local reaction of the coral-derived biphasic CaPs bone graft on tissue. The results confirmed that the co-existence of β-TCP and HAp was formed at 1100 °C for 1 h. The ratio of HA/β-TCP increased as the heat-treatment time increased. The coral-derived biphasic CaPs comprising 61% HAp and 39% β-TCP (defined as HT-3) were not cytotoxic. Furthermore, no significant differences in local tissue reaction were observed between the HT-3 sample and autogenous bone. Therefore, the synthesized coral-derived biphasic CaPs is a candidate for bone grafting due to its good biocompatibility. View Full-Text
Keywords: bioactive materials; bioceramics; biocompatibility; composites; calcium phosphate bioactive materials; bioceramics; biocompatibility; composites; calcium phosphate
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MDPI and ACS Style

Lin, H.-Y.; Lu, Y.-J.; Chou, H.-H.; Ou, K.-L.; Huang, B.-H.; Lan, W.-C.; Saito, T.; Cho, Y.-C.; Ou, Y.-H.; Yang, T.-S.; Peng, P.-W. Biomimetic Ceramic Composite: Characterization, Cell Response, and In Vivo Biocompatibility. Materials 2021, 14, 7374. https://doi.org/10.3390/ma14237374

AMA Style

Lin H-Y, Lu Y-J, Chou H-H, Ou K-L, Huang B-H, Lan W-C, Saito T, Cho Y-C, Ou Y-H, Yang T-S, Peng P-W. Biomimetic Ceramic Composite: Characterization, Cell Response, and In Vivo Biocompatibility. Materials. 2021; 14(23):7374. https://doi.org/10.3390/ma14237374

Chicago/Turabian Style

Lin, Hung-Yang, Yi-Jung Lu, Hsin-Hua Chou, Keng-Liang Ou, Bai-Hung Huang, Wen-Chien Lan, Takashi Saito, Yung-Chieh Cho, Yu-Hsin Ou, Tzu-Sen Yang, and Pei-Wen Peng. 2021. "Biomimetic Ceramic Composite: Characterization, Cell Response, and In Vivo Biocompatibility" Materials 14, no. 23: 7374. https://doi.org/10.3390/ma14237374

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