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Open AccessArticle

Antibacterial PEGylated Solid Lipid Microparticles for Cosmeceutical Purpose: Formulation, Characterization, and Efficacy Evaluation

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Dipartimento di Discipline Chirurgiche, Oncologiche e Stomatologiche, Università degli Studi di Palermo, 90127 Palermo, Italy
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Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF) Università degli Studi di Palermo, 90128 Palermo, Italy
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Dipartimento di Fisica e Chimica, Università degli Studi Palermo, 90128 Palermo, Italy
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Author to whom correspondence should be addressed.
Materials 2020, 13(9), 2073; https://doi.org/10.3390/ma13092073
Received: 5 April 2020 / Revised: 21 April 2020 / Accepted: 28 April 2020 / Published: 30 April 2020
(This article belongs to the Special Issue Nanocomposites as Effective and Targeted Antibacterial Agents)
The development of efficacious means of delivering antioxidant polyphenols from natural sources for the treatment of skin diseases is of great interest for many cosmetic and pharmaceutical companies. Resveratrol (RSV) and Limonene (LIM) have been shown to possess good anti-inflammatory and antibacterial properties against Staphylococcus aureus infections responsible for many skin disorders, such as acne vulgaris. In this study, solid lipid microparticles are designed as composite vehicles capable of encapsulating a high amount of trans-RSV and enhancing its absorption through the stratum corneum. A microparticulate system based on mixture of PEGylate lipids, long-chain alcohols and LIM is able to entrap RSV in an amorphous state, increasing its half-life and avoiding inactivation due to isomerization phenomena, which represents the main drawback in topical formulations. Particles have been characterized in term of shape, size distribution and drug loading. Antimicrobial tests against S. aureus have highlighted that empty microspheres possess per se antimicrobial activity, which is enhanced by the presence of LIM, demonstrating that they can represent an interesting bactericide vehicle for RSV administration on the skin. View Full-Text
Keywords: solid lipid microparticles; lipid microspheres; Resveratrol; Limonene; 1-Hexadecanol; Labrasol; antimicrobial activity; tape-stripping; Staphylococcus aureus ATCC 25923; porcine ears solid lipid microparticles; lipid microspheres; Resveratrol; Limonene; 1-Hexadecanol; Labrasol; antimicrobial activity; tape-stripping; Staphylococcus aureus ATCC 25923; porcine ears
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MDPI and ACS Style

Angellotti, G.; Murgia, D.; Presentato, A.; D’Oca, M.C.; Scarpaci, A.G.; Alduina, R.; Raimondi, M.V.; De Caro, V. Antibacterial PEGylated Solid Lipid Microparticles for Cosmeceutical Purpose: Formulation, Characterization, and Efficacy Evaluation. Materials 2020, 13, 2073.

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