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Utilization of Finite Element Analysis for Articular Cartilage Tissue Engineering

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Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
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Department of Orthopaedics, Stony Brook University, Stony Brook, NY 11794, USA
*
Author to whom correspondence should be addressed.
Materials 2019, 12(20), 3331; https://doi.org/10.3390/ma12203331
Received: 17 September 2019 / Revised: 2 October 2019 / Accepted: 8 October 2019 / Published: 12 October 2019
(This article belongs to the Special Issue Advanced Nanosciences Applied in Tissue Engineering and Drug Delivery)
Scaffold design plays an essential role in tissue engineering of articular cartilage by providing the appropriate mechanical and biological environment for chondrocytes to proliferate and function. Optimization of scaffold design to generate tissue-engineered cartilage has traditionally been conducted using in-vitro and in-vivo models. Recent advances in computational analysis allow us to significantly decrease the time and cost of scaffold optimization using finite element analysis (FEA). FEA is an in-silico analysis technique that allows for scaffold design optimization by predicting mechanical responses of cells and scaffolds under applied loads. Finite element analyses can potentially mimic the morphology of cartilage using mesh elements (tetrahedral, hexahedral), material properties (elastic, hyperelastic, poroelastic, composite), physiological loads by applying loading conditions (static, dynamic), and constitutive stress–strain equations (linear, porous–elastic, biphasic). Furthermore, FEA can be applied to the study of the effects of dynamic loading, material properties cell differentiation, cell activity, scaffold structure optimization, and interstitial fluid flow, in isolated or combined multi-scale models. This review covers recent studies and trends in the use of FEA for cartilage tissue engineering and scaffold design. View Full-Text
Keywords: articular cartilage; tissue engineering; scaffold design; finite element analysis articular cartilage; tissue engineering; scaffold design; finite element analysis
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MDPI and ACS Style

Hassan, C.R.; Qin, Y.-X.; Komatsu, D.E.; Uddin, S.M. Utilization of Finite Element Analysis for Articular Cartilage Tissue Engineering. Materials 2019, 12, 3331.

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