Next Article in Journal
Laser Machining and In Vitro Assessment of Wollastonite-Tricalcium Phosphate Eutectic Glasses and Glass-Ceramics
Next Article in Special Issue
Anticancer Applications of Nanostructured Silica-Based Materials Functionalized with Titanocene Derivatives: Induction of Cell Death Mechanism through TNFR1 Modulation
Previous Article in Journal
Effect of Exposed Surface Area, Volume and Environmental pH on the Calcium Ion Release of Three Commercially Available Tricalcium Silicate Based Dental Cements
Previous Article in Special Issue
Nitrogen-Doped Diamond Film for Optical Investigation of Hemoglobin Concentration
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessFeature PaperArticle
Materials 2018, 11(1), 122; https://doi.org/10.3390/ma11010122

Biopolymer-Based Nanoparticles for Cystic Fibrosis Lung Gene Therapy Studies

1
Lung Biology Group, Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
2
ChiPro GmbH, Anne-Conway-Straße 1, 28359 Bremen, Germany
3
School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland
4
School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland
5
Aerogen Ltd., Galway Business Park, Dangan, Galway H91 HE94, Ireland
*
Author to whom correspondence should be addressed.
Received: 30 November 2017 / Revised: 4 January 2018 / Accepted: 8 January 2018 / Published: 13 January 2018
(This article belongs to the Special Issue Nanomaterials for Biomedical Applications)
Full-Text   |   PDF [3564 KB, uploaded 13 January 2018]   |  

Abstract

Lung gene therapy for cystic fibrosis disease has not been successful due to several challenges such as the absence of an appropriate vector. Therefore, optimal delivery of emerging therapeutics to airway epithelial cells demands suitable non-viral systems. In this work, we describe the formulation and the physicochemical investigation of biocompatible and biodegradable polymeric nanoparticles (NPs), including PLGA and chitosan (animal and non-animal), as novel methods for the safe and efficient delivery of CFTR-specific locked nucleic acids (LNAs). View Full-Text
Keywords: cystic fibrosis; cystic fibrosis transmembrane conductance regulator (CFTR); lung gene delivery; nanoparticles; biopolymers; PLGA; chitosan; Locked-Nucleic Acid (LNA) cystic fibrosis; cystic fibrosis transmembrane conductance regulator (CFTR); lung gene delivery; nanoparticles; biopolymers; PLGA; chitosan; Locked-Nucleic Acid (LNA)
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Fernández Fernández, E.; Santos-Carballal, B.; de Santi, C.; Ramsey, J.M.; MacLoughlin, R.; Cryan, S.-A.; Greene, C.M. Biopolymer-Based Nanoparticles for Cystic Fibrosis Lung Gene Therapy Studies. Materials 2018, 11, 122.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top