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Open AccessArticle

The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting

Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea
School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore
Biomedical Implant Convergence Research Center, Advanced Institutes of Convergence Technology, Suwon 443-270, Korea
Liquid Processing & Casting Technology R&D Group, Korea Institute of Industrial Technology, Incheon 406-840, Korea
Author to whom correspondence should be addressed.
Academic Editor: Tobias Fey
Materials 2017, 10(4), 367;
Received: 30 January 2017 / Revised: 15 March 2017 / Accepted: 27 March 2017 / Published: 31 March 2017
(This article belongs to the Special Issue Porous Ceramics)
Porous hydroxyapatite (HA) scaffolds with porosity-graded structures were fabricated by sequential freeze-casting. The pore structures, compressive strengths, and biocompatibilities of the fabricated porous HA scaffolds were evaluated. The porosities of the inner and outer layers of the graded HA scaffolds were controlled by adjusting the initial HA contents of the casting slurries. The interface between the dense and porous parts was compact and tightly adherent. The porosity and compressive strengths of the scaffold were controlled by the relative thicknesses of the dense/porous parts. In addition, the porous HA scaffolds showed good biocompatibility in terms of preosteoblast cell attachment and proliferation. The results suggest that porous HA scaffolds with load-bearing parts have potential as bone grafts in hard-tissue engineering. View Full-Text
Keywords: freeze-casting; porous materials; porosity; graded structure; compressive strengths freeze-casting; porous materials; porosity; graded structure; compressive strengths
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MDPI and ACS Style

Lee, H.; Jang, T.-S.; Song, J.; Kim, H.-E.; Jung, H.-D. The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting. Materials 2017, 10, 367.

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