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Preparation and Investigation of Amphiphilic Block Copolymers/Fullerene Nanocomposites as Nanocarriers for Hydrophobic Drug

Key Laboratory for Advanced Civil Engineering Materials (Ministry of Education), School of Materials Science and Engineering, Tongji University, Caoan Road 4800, Shanghai 201804, China
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Academic Editor: Dusan Losic
Materials 2017, 10(2), 192; https://doi.org/10.3390/ma10020192
Received: 12 January 2017 / Revised: 5 February 2017 / Accepted: 15 February 2017 / Published: 16 February 2017
(This article belongs to the Section Biomaterials)
Biopolymer/inorganic material nanocomposites have attracted increasing interest as nanocarriers for delivering drugs owing to the combined advantages of both biopolymer and inorganic materials. Here, amphiphilic block copolymer/fullerene nanocomposites were prepared as nanocarriers for hydrophobic drug by incorporation of C60 in the core of methoxy polyethylene glycol-poly(d,l-lactic acid) (MPEG-PDLLA) micelles. The structure and morphology of MPEG-PDLLA/C60 nanocomposites were characterized using transmission electron microscopy, dynamic light scattering, high-resolution transmission electron microscopy, and thermal gravimetric analysis. It was found that the moderate amount of spherical C60 incorporated in the MPEG-PDLLA micelles may cause an increase in the molecular chain space of PDLLA segments in the vicinity of C60 and, thus, produce a larger cargo space to increase drug entrapment and accelerate the drug release from nanocomposites. Furthermore, sufficient additions of C60 perhaps resulted in an aggregation of C60 within the micelles that decreased the drug entrapment and produced a steric hindrance for DOX released from the nanocomposites. The results obtained provide fundamental insights into the understanding of the role of C60 in adjusting the drug loading and release of amphiphilic copolymer micelles and further demonstrate the future potential of the MPEG-PDLLA/C60 nanocomposites used as nanocarriers for controlled drug-delivery applications. View Full-Text
Keywords: nanocarriers; nanocomposites; amphiphilic block copolymers; fullerene; controlled drug delivery nanocarriers; nanocomposites; amphiphilic block copolymers; fullerene; controlled drug delivery
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Tan, Q.; Chu, Y.; Bie, M.; Wang, Z.; Xu, X. Preparation and Investigation of Amphiphilic Block Copolymers/Fullerene Nanocomposites as Nanocarriers for Hydrophobic Drug. Materials 2017, 10, 192.

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