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Case Report

Spontaneous Regression of Metastatic Renal Cell Carcinoma after SARS-CoV-2 Infection: A Report of Two Cases

1
Department of Oncology, First Faculty of Medicine, Charles University and Thomayer University Hospital, 14059 Prague, Czech Republic
2
Department of Urology, District Hospital Kladno, 27201 Kladno, Czech Republic
3
Department of Radiology, District Hospital Kladno, 27201 Kladno, Czech Republic
4
Department of Radiology, Medicon, 14000 Prague, Czech Republic
5
Department of Radiology, Thomayer University Hospital, 14059 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(5), 3403-3407; https://doi.org/10.3390/curroncol28050294
Received: 16 August 2021 / Revised: 31 August 2021 / Accepted: 2 September 2021 / Published: 3 September 2021
(This article belongs to the Section Genitourinary Oncology)
Spontaneous regression of metastatic renal cell carcinoma (mRCC) is a rare event, often associated with an activation of innate immunity by various triggers. SARS-CoV-2 infection induces a strong inflammatory response in some patients and a cytokine storm is one of the main causes of severe morbidity and mortality associated with the virus. Here, we describe two cases of patients with histologically and radiologically proven mRCC whose treatment was delayed due to COVID-19 and who experienced spontaneous tumour regression following the infection. Both patients reported here had predominantly pulmonary and mediastinal involvement and underwent nephrectomy. The interval between the diagnosis of COVID-19 and the detection of tumour regression was 3 and 4 months, respectively. Although approved vaccines and other measures are clearly the best way to prevent COVID-19-associated morbidity and mortality in cancer patients, we hypothesize that innate immunity activation by the infection can contribute to tumour regression in special circumstances. View Full-Text
Keywords: renal cell carcinoma; spontaneous regression; COVID-19; SARS-CoV-2; innate immunity renal cell carcinoma; spontaneous regression; COVID-19; SARS-CoV-2; innate immunity
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MDPI and ACS Style

Buchler, T.; Fiser, L.; Benesova, J.; Jirickova, H.; Votrubova, J. Spontaneous Regression of Metastatic Renal Cell Carcinoma after SARS-CoV-2 Infection: A Report of Two Cases. Curr. Oncol. 2021, 28, 3403-3407. https://doi.org/10.3390/curroncol28050294

AMA Style

Buchler T, Fiser L, Benesova J, Jirickova H, Votrubova J. Spontaneous Regression of Metastatic Renal Cell Carcinoma after SARS-CoV-2 Infection: A Report of Two Cases. Current Oncology. 2021; 28(5):3403-3407. https://doi.org/10.3390/curroncol28050294

Chicago/Turabian Style

Buchler, Tomas, Lukas Fiser, Jaroslava Benesova, Hana Jirickova, and Jana Votrubova. 2021. "Spontaneous Regression of Metastatic Renal Cell Carcinoma after SARS-CoV-2 Infection: A Report of Two Cases" Current Oncology 28, no. 5: 3403-3407. https://doi.org/10.3390/curroncol28050294

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