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Current Oncology
Volume 26
Issue 5
10.3747/co.26.5179
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

Primary Yolk Sac Tumour of the Prostate Mimicking Small Round Blue Cell Tumour

by
H. Gui
1,*,
R.A. Kolster
2,
M.B. Palmer
2,
J.S. Brooks
1,
M. Zhang
1 and
M.A. Husson
1,*
1
Department of Pathology and Laboratory Medicine, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, PA, USA
2
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
*
Authors to whom correspondence should be addressed.
Curr. Oncol. 2019, 26(5), 707-711; https://doi.org/10.3747/co.26.5179
Submission received: 9 July 2019 / Revised: 12 August 2019 / Accepted: 11 September 2019 / Published: 1 October 2019

Abstract

Prostatic yolk sac tumour is a germ cell tumour with a wide range of age of occurrence, unusual anatomic locations, diverse morphologic patterns, and aggressive biologic behavior, posing challenges both to diagnosis and clinical management. We report a rare case of primary yolk sac tumour of the prostate with extensive local and liver metastasis, the latter of which exhibited sheets of small blue cells expressing CD99 and focal sall4 on biopsy. Positivity for CD99 and gata3 in the initial biopsy raised the differential diagnosis of Ewing sarcoma and poorly differentiated carcinoma. The primary tumour demonstrated an admixture of solid and glandular growth patterns and occasional Schiller–Duval bodies. A panel of immunohistochemical stains showing positivity for AE1/3, sall4, cdx2, and focal alpha-fetoprotein, and negativity for oct-4, facilitated the diagnosis. A thorough review of the literature and our current report indicate that a large tumour load, incomplete tumour resection, limited response to preoperative neoadjuvant chemotherapy, and late stage of the disease are predictive factors for a poor clinical outcome.
Keywords: yolk sac tumours; germ cell tumours; prostate yolk sac tumours; germ cell tumours; prostate

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MDPI and ACS Style

Gui, H.; Kolster, R.A.; Palmer, M.B.; Brooks, J.S.; Zhang, M.; Husson, M.A. Primary Yolk Sac Tumour of the Prostate Mimicking Small Round Blue Cell Tumour. Curr. Oncol. 2019, 26, 707-711. https://doi.org/10.3747/co.26.5179

AMA Style

Gui H, Kolster RA, Palmer MB, Brooks JS, Zhang M, Husson MA. Primary Yolk Sac Tumour of the Prostate Mimicking Small Round Blue Cell Tumour. Current Oncology. 2019; 26(5):707-711. https://doi.org/10.3747/co.26.5179

Chicago/Turabian Style

Gui, H., R.A. Kolster, M.B. Palmer, J.S. Brooks, M. Zhang, and M.A. Husson. 2019. "Primary Yolk Sac Tumour of the Prostate Mimicking Small Round Blue Cell Tumour" Current Oncology 26, no. 5: 707-711. https://doi.org/10.3747/co.26.5179

APA Style

Gui, H., Kolster, R. A., Palmer, M. B., Brooks, J. S., Zhang, M., & Husson, M. A. (2019). Primary Yolk Sac Tumour of the Prostate Mimicking Small Round Blue Cell Tumour. Current Oncology, 26(5), 707-711. https://doi.org/10.3747/co.26.5179

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