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Current Oncology
Volume 24
Issue 3
10.3747/co.24.3486
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Efficacy of Metronomic Vinorelbine in Elderly Patients with Advanced Non-Small-Cell Lung Cancer and Poor Performance Status

by
Cemil Bilir
1,*,
S. Durak
2,
B. Kızılkaya
2,
I. Hacıbekiroglu
3,
E. Nayır
4 and
H. Engin
1
1
Department of Medical Oncology, Faculty of Medicine, Sakarya University, Korucuk Mahallesi Konuralp Bulvarı No. 81/1, Korucuk Kampüsü, Adapazarı, Sakarya, Turkey
2
Department of Internal Medicine, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey
3
Department of Medical Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey
4
Department of Medical Oncology, Necip Fazıl City Hospital, Kahramanmaras, Turkey
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2017, 24(3), 199-204; https://doi.org/10.3747/co.24.3486
Submission received: 4 March 2017 / Revised: 5 April 2017 / Accepted: 9 May 2017 / Published: 1 June 2017

Abstract

Background: Metronomic chemotherapy—administration of low-dose chemotherapy—allows for a prolonged treatment duration and minimizes toxicity for unfit patients diagnosed with advanced non-small-cell lung cancer (NSCLC). Methods: Oral metronomic vinorelbine at 30 mg thrice weekly was given to 35 chemotherapy-naïve patients who were elderly and vulnerable to toxicity and who had been diagnosed with advanced NSCLC. Results: Median age in this male-predominant cohort (29:6) was 76 years (range: 65–86 years). Histology was squamous cell carcinoma in 21 patients and adenocarcinoma in 14. There were no complete responses and 9 partial responses, for an overall response rate of 26%. Stable disease was seen in 15 patients (43%), and 11 patients (31%) had progressive disease. The 1-year survival rate was 34%, and the 2-year survival rate was 8%. The survival analysis showed a median progression-free survival duration of 4 months (range: 2–15 months) and an overall survival duration of 7 months (range: 3–24 months). Conclusions: Metronomic vinorelbine had an acceptable efficacy and safety profile in elderly patients with multiple comorbidities who had been diagnosed with advanced NSCLC. Metronomic vinorelbine could be a treatment option for elderly patients with poor performance status who are unfit for platinum-based chemotherapy and intravenous single-agent chemotherapy, and who are not candidates for combination modalities.
Keywords: metronomic vinorelbine; non-small-cell lung cancer; poor performance status metronomic vinorelbine; non-small-cell lung cancer; poor performance status

Share and Cite

MDPI and ACS Style

Bilir, C.; Durak, S.; Kızılkaya, B.; Hacıbekiroglu, I.; Nayır, E.; Engin, H. Efficacy of Metronomic Vinorelbine in Elderly Patients with Advanced Non-Small-Cell Lung Cancer and Poor Performance Status. Curr. Oncol. 2017, 24, 199-204. https://doi.org/10.3747/co.24.3486

AMA Style

Bilir C, Durak S, Kızılkaya B, Hacıbekiroglu I, Nayır E, Engin H. Efficacy of Metronomic Vinorelbine in Elderly Patients with Advanced Non-Small-Cell Lung Cancer and Poor Performance Status. Current Oncology. 2017; 24(3):199-204. https://doi.org/10.3747/co.24.3486

Chicago/Turabian Style

Bilir, Cemil, S. Durak, B. Kızılkaya, I. Hacıbekiroglu, E. Nayır, and H. Engin. 2017. "Efficacy of Metronomic Vinorelbine in Elderly Patients with Advanced Non-Small-Cell Lung Cancer and Poor Performance Status" Current Oncology 24, no. 3: 199-204. https://doi.org/10.3747/co.24.3486

APA Style

Bilir, C., Durak, S., Kızılkaya, B., Hacıbekiroglu, I., Nayır, E., & Engin, H. (2017). Efficacy of Metronomic Vinorelbine in Elderly Patients with Advanced Non-Small-Cell Lung Cancer and Poor Performance Status. Current Oncology, 24(3), 199-204. https://doi.org/10.3747/co.24.3486

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