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Current Oncology
Volume 22
Issue 4
10.3747/co.22.2467
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

Unusual Presentation of Metastatic Sebaceous Crcinoma and Its Response to Chemotherapy: Is Genotyping a Right Answer for Guiding Chemotherapy in Rare Tumours?

by
V. Kumar
1,* and
Y. Xu
2
1
Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY, USA
2
Department of Internal Medicine, Division of Hematology Oncology, Maimonides Medical Center, Brooklyn, NY, USA
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2015, 22(4), 316-319; https://doi.org/10.3747/co.22.2467
Submission received: 3 May 2015 / Revised: 6 June 2015 / Accepted: 7 July 2015 / Published: 1 August 2015

Abstract

Sebaceous carcinoma is a rare malignant tumour of skin. It commonly occurs in the head and neck region. The standard of care for localized disease is wide local excision followed by radiotherapy. Occasionally, sebaceous carcinoma can be associated with Muir–Torre syndrome, which is characterized by sebaceous lesions and carcinomas in the visceral organs. Metastatic sebaceous carcinoma is even rarer, with very little evidence about the role of chemotherapy in the treatment of metastatic disease. Here, we report a case of recurrent sebaceous carcinoma metastatic to the rectum (initially mimicking rectal cancer and Muir–Torre syndrome) in which the disease responded to multiple lines of chemotherapy. We also review the available literature on chemotherapy in this disease and discuss the role of tumour profiling and genotypeguided selection of chemotherapeutics in such rare tumours.
Keywords: metastatic sebaceous carcinoma; genotyping; tumour profiles; Muir–Torre syndrome metastatic sebaceous carcinoma; genotyping; tumour profiles; Muir–Torre syndrome

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MDPI and ACS Style

Kumar, V.; Xu, Y. Unusual Presentation of Metastatic Sebaceous Crcinoma and Its Response to Chemotherapy: Is Genotyping a Right Answer for Guiding Chemotherapy in Rare Tumours? Curr. Oncol. 2015, 22, 316-319. https://doi.org/10.3747/co.22.2467

AMA Style

Kumar V, Xu Y. Unusual Presentation of Metastatic Sebaceous Crcinoma and Its Response to Chemotherapy: Is Genotyping a Right Answer for Guiding Chemotherapy in Rare Tumours? Current Oncology. 2015; 22(4):316-319. https://doi.org/10.3747/co.22.2467

Chicago/Turabian Style

Kumar, V., and Y. Xu. 2015. "Unusual Presentation of Metastatic Sebaceous Crcinoma and Its Response to Chemotherapy: Is Genotyping a Right Answer for Guiding Chemotherapy in Rare Tumours?" Current Oncology 22, no. 4: 316-319. https://doi.org/10.3747/co.22.2467

APA Style

Kumar, V., & Xu, Y. (2015). Unusual Presentation of Metastatic Sebaceous Crcinoma and Its Response to Chemotherapy: Is Genotyping a Right Answer for Guiding Chemotherapy in Rare Tumours? Current Oncology, 22(4), 316-319. https://doi.org/10.3747/co.22.2467

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