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Current Oncology
Volume 22
Issue 4
10.3747/co.22.2259
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

In Serum, Higher Parathyroid Hormone but Not Lower Vitamin D Is Associated with Oral Squamous Cell Carcinoma

by
H. Zhang
1,
H. Lu
1,
C. Shrestha
1,
Y. Feng
2,
Y. Li
2,
J. Peng
1,
Y. Li
3 and
Z. Xie
1
1
Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China
2
Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, China
3
Stomatological Hospital of Xiangtan, Xiangtan, China
Curr. Oncol. 2015, 22(4), 259-263; https://doi.org/10.3747/co.22.2259
Submission received: 8 May 2015 / Revised: 8 June 2015 / Accepted: 5 July 2015 / Published: 1 August 2015

Abstract

Introduction: Vitamin D and calcium are known to regulate differentiation and proliferation of keratinocytes; they might potentially have a role in suppressing carcinogenesis in squamous epithelium. Serum parathyroid hormone (pth) is a sensitive indicator of calcium and vitamin D deficiency, and 25-hydroxyvitamin D [25(OH)D] is an established marker of vitamin D status. Methods: To determine whether levels of 25(OH)D, calcium, or pth in serum are associated with oral squamous cell carcinoma (oscc), we examined those parameters in serum collected from 70 patients with oscc and from an equal number of matched control subjects. Results: The results showed that intact pth was significantly higher in serum from oscc patients than in serum from control subjects. However, we observed no significant differences in 25(OH)D or calcium in serum from oscc patients and from control subjects. Conclusions: We conclude that higher serum pth, but not lower serum vitamin D or calcium, is associated with oscc.
Keywords: Oral squamous cell carcinoma; parathyroid hormone; 25-hydroxyvitamin D; calcium Oral squamous cell carcinoma; parathyroid hormone; 25-hydroxyvitamin D; calcium

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MDPI and ACS Style

Zhang, H.; Lu, H.; Shrestha, C.; Feng, Y.; Li, Y.; Peng, J.; Li, Y.; Xie, Z. In Serum, Higher Parathyroid Hormone but Not Lower Vitamin D Is Associated with Oral Squamous Cell Carcinoma. Curr. Oncol. 2015, 22, 259-263. https://doi.org/10.3747/co.22.2259

AMA Style

Zhang H, Lu H, Shrestha C, Feng Y, Li Y, Peng J, Li Y, Xie Z. In Serum, Higher Parathyroid Hormone but Not Lower Vitamin D Is Associated with Oral Squamous Cell Carcinoma. Current Oncology. 2015; 22(4):259-263. https://doi.org/10.3747/co.22.2259

Chicago/Turabian Style

Zhang, H., H. Lu, C. Shrestha, Y. Feng, Y. Li, J. Peng, Y. Li, and Z. Xie. 2015. "In Serum, Higher Parathyroid Hormone but Not Lower Vitamin D Is Associated with Oral Squamous Cell Carcinoma" Current Oncology 22, no. 4: 259-263. https://doi.org/10.3747/co.22.2259

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