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Current Oncology
Volume 21
Issue 1
10.3747/co.21.1711
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Diagnostic Value of Preoperative Serum Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 in Colorectal Cancer

by
E. Polat
1,
U. Duman
2,*,
M. Duman
1,
A.E. Atici
1,
E. Reyhan
1,
T. Dalgic
3,
E.B. Bostanci
3 and
S. Yol
1
1
Department of Gastrointestinal Surgery, Kartal Kosuyolu High Specialty Training and Research Hospital, Istanbul, Turkey
2
Department of General Surgery, Bursa Sevket Yilmaz Training and Research Hospital, Bursa, Turkey
3
Department of Gastrointestinal Surgery, Turkiye High Specialty Training and Research Hospital, Ankara, Turkey
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2014, 21(1), 1-7; https://doi.org/10.3747/co.21.1711
Submission received: 10 December 2013 / Revised: 1 January 2014 / Accepted: 5 January 2014 / Published: 1 February 2014

Abstract

Background: Since the first introduction of tumour markers, their usefulness for diagnosis has been a challenging question. The aim of the present prospective study was to investigate, in colorectal cancer patients, the relationship between preoperative tumour marker concentrations and various clinical variables. Methods: The study prospectively enrolled 131 consecutive patients with a confirmed diagnosis of colorectal carcinoma and 131 age- and sex-matched control subjects with no malignancy. The relationships of the tumour markers carcinoembryonic antigen (cea) and carbohydrate antigen (ca) 19-9 with disease stage, tumour differentiation (grade), mucus production, liver function tests, T stage, N stage, M stage were investigated. Results: Serum concentrations of cea were significantly higher in the patient group than in the control group (p = 0.001); they were also significantly higher in stage iii (p = 0.018) and iv disease (p = 0.001) than in stage i. Serum concentrations of cea were significantly elevated in the presence of spread to lymph nodes (p = 0.005) in the patient group. Levels of both tumour markers were significantly elevated in the presence of distant metastasis in the patient group (p = 0.005 for cea; p = 0.004 for ca 19-9). Conclusions: Preoperative levels of cea and ca 19-9 might provide an estimate of lymph node invasion and distant metastasis in colorectal cancer patients.
Keywords: carbohydrate antigen 19-9; carcinoembryonic antigen; colorectal cancer carbohydrate antigen 19-9; carcinoembryonic antigen; colorectal cancer

Share and Cite

MDPI and ACS Style

Polat, E.; Duman, U.; Duman, M.; Atici, A.E.; Reyhan, E.; Dalgic, T.; Bostanci, E.B.; Yol, S. Diagnostic Value of Preoperative Serum Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 in Colorectal Cancer. Curr. Oncol. 2014, 21, 1-7. https://doi.org/10.3747/co.21.1711

AMA Style

Polat E, Duman U, Duman M, Atici AE, Reyhan E, Dalgic T, Bostanci EB, Yol S. Diagnostic Value of Preoperative Serum Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 in Colorectal Cancer. Current Oncology. 2014; 21(1):1-7. https://doi.org/10.3747/co.21.1711

Chicago/Turabian Style

Polat, E., U. Duman, M. Duman, A.E. Atici, E. Reyhan, T. Dalgic, E.B. Bostanci, and S. Yol. 2014. "Diagnostic Value of Preoperative Serum Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 in Colorectal Cancer" Current Oncology 21, no. 1: 1-7. https://doi.org/10.3747/co.21.1711

APA Style

Polat, E., Duman, U., Duman, M., Atici, A. E., Reyhan, E., Dalgic, T., Bostanci, E. B., & Yol, S. (2014). Diagnostic Value of Preoperative Serum Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 in Colorectal Cancer. Current Oncology, 21(1), 1-7. https://doi.org/10.3747/co.21.1711

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