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Current Oncology
Volume 20
Issue 4
10.3747/co.20.1380
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Serum Insulin-Like Growth Factor 1 Correlates with the Risk of Nodal Metastasis in Endocrine-Positive Breast Cancer

by
F. Morgillo
1,
F. De Vita
1,
G. Antoniol
2,
M. Orditura
1,
P.P. Auriemma
3,
M.R. Diadema
1,
E. Lieto
3,
B. Savastano
1,
L. Festino
1,
M.M. Laterza
1,
A. Fabozzi
1,
J. Ventriglia
1,
A. Petrillo
1,
F. Ciardiello
1,
A. Barbarisi
3 and
F. Iovino
3,*
1
Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale “F.Magrassi e A. Lanzara”, Seconda Università degli Studi di Napoli, Napoli, Italy
2
Dèpartement de Génie Informatique et Génie Logiciel, École Polytechnique de Montréal, Montreal, QC, Canada
3
IX Divisione di Chirurgia Generale, Dipartimento di Scienze Anestesiologiche, Chirurgiche e dell’Emergenza, Seconda Università degli Studi di Napoli, Napoli, Italy
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2013, 20(4), 283-288; https://doi.org/10.3747/co.20.1380
Submission received: 8 May 2013 / Revised: 3 June 2013 / Accepted: 10 July 2013 / Published: 1 August 2013

Abstract

Increased insulin-like growth factor (IGF) signalling has been observed in breast cancer, including endocrine-responsive cancers, and has been linked to disease progression and recurrence. In particular, IGF-1 has the ability to induce and promote lymphangiogenesis through the induction of vascular endothelial growth factor C (VEGFC). In the present study, we analyzed serum and tumour samples from 60 patients with endocrine-positive breast cancer to determine the expression and the possible relationship of circulating IGF-1, IGF binding protein 3 (IGFBP3), and VEGFC with the presence of lymphatic metastasis and other immunohistochemical parameters. The analysis revealed a clear and significant correlation between high basal levels of IGF-1, IGFBP3, and VEGFC and lymph node metastasis in endocrine-responsive breast cancer. In addition, expression of those molecules was significantly higher in breast cancer patients than in healthy control subjects. Those findings may enable more accurate prediction of prognosis in patients with breast cancer.
Keywords: breast cancer; igf-1; vegfc breast cancer; igf-1; vegfc

Share and Cite

MDPI and ACS Style

Morgillo, F.; De Vita, F.; Antoniol, G.; Orditura, M.; Auriemma, P.P.; Diadema, M.R.; Lieto, E.; Savastano, B.; Festino, L.; Laterza, M.M.; et al. Serum Insulin-Like Growth Factor 1 Correlates with the Risk of Nodal Metastasis in Endocrine-Positive Breast Cancer. Curr. Oncol. 2013, 20, 283-288. https://doi.org/10.3747/co.20.1380

AMA Style

Morgillo F, De Vita F, Antoniol G, Orditura M, Auriemma PP, Diadema MR, Lieto E, Savastano B, Festino L, Laterza MM, et al. Serum Insulin-Like Growth Factor 1 Correlates with the Risk of Nodal Metastasis in Endocrine-Positive Breast Cancer. Current Oncology. 2013; 20(4):283-288. https://doi.org/10.3747/co.20.1380

Chicago/Turabian Style

Morgillo, F., F. De Vita, G. Antoniol, M. Orditura, P.P. Auriemma, M.R. Diadema, E. Lieto, B. Savastano, L. Festino, M.M. Laterza, and et al. 2013. "Serum Insulin-Like Growth Factor 1 Correlates with the Risk of Nodal Metastasis in Endocrine-Positive Breast Cancer" Current Oncology 20, no. 4: 283-288. https://doi.org/10.3747/co.20.1380

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