The Prognostic Role of miR-31 in Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-Analysis with Trial Sequential Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Protocol
2.2. Eligibility Criteria
2.3. Sources of Information, Research, and Selection
2.4. Data Collection Process, Data Characteristics
2.5. Risk of Bias in Individual Studies, Summary Measures, Summary of Results, Risk of Bias between Studies, Additional Measures
3. Results
3.1. Selection of Studies
3.2. Data Characteristics
3.3. Risk of Bias in Studies
3.4. Meta-Analysis
3.5. Risk of Bias across Study
3.6. Trial Sequential Analysis, Grade
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Identification Records through Databases and Registers | |||
---|---|---|---|
Databases | k-Words | Search Details | Number |
PubMed | miR-31 AND HNSCC | Search: miR-31 AND HNSCC Sort by: Most Recent “miR-31”[All Fields] AND (“hnsccs”[All Fields] OR “squamous cell carcinoma of head and neck”[MeSH Terms] OR (“squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields] AND “head”[All Fields] AND “neck”[All Fields]) OR “squamous cell carcinoma of head and neck”[All Fields] OR “hnscc”[All Fields]) Translations HNSCC: “hnsccs”[All Fields] OR “squamous cell carcinoma of head and neck”[MeSH Terms] OR (“squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields] AND “head”[All Fields] AND “neck”[All Fields]) OR “squamous cell carcinoma of head and neck”[All Fields] OR “hnscc”[All Fields] | 34 |
Microrna AND HNSCC AND prognosis | Search: Microrna AND HNSCC AND prognosis Sort by: Most Recent (“microrna s”[All Fields] OR “micrornas”[MeSH Terms] OR “micrornas”[All Fields] OR “microrna”[All Fields]) AND (“hnsccs”[All Fields] OR “squamous cell carcinoma of head and neck”[MeSH Terms] OR (“squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields] AND “head”[All Fields] AND “neck”[All Fields]) OR “squamous cell carcinoma of head and neck”[All Fields] OR “hnscc”[All Fields]) AND (“prognosis”[MeSH Terms] OR “prognosis”[All Fields] OR “prognoses”[All Fields]) Translations Microrna: “microrna’s”[All Fields] OR “micrornas”[MeSH Terms] OR “micrornas”[All Fields] OR “microrna”[All Fields] HNSCC: “hnsccs”[All Fields] OR “squamous cell carcinoma of head and neck”[MeSH Terms] OR (“squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields] AND “head”[All Fields] AND “neck”[All Fields]) OR “squamous cell carcinoma of head and neck”[All Fields] OR “hnscc”[All Fields] prognosis: “prognosis”[MeSH Terms] OR “prognosis”[All Fields] OR “prognoses”[All Fields] | 395 | |
miR-31 AND OSCC | Search: miR-31 AND OSCC Sort by: Most Recent “miR-31”[All Fields] AND “OSCC”[All Fields] | 25 | |
miR-31 AND laryngeal cancer | Search: miR-31 AND laryngeal cancer Sort by: Most Recent “miR-31”[All Fields] AND (“laryngeal neoplasms”[MeSH Terms] OR (“laryngeal”[All Fields] AND “neoplasms”[All Fields]) OR “laryngeal neoplasms”[All Fields] OR (“laryngeal”[All Fields] AND “cancer”[All Fields]) OR “laryngeal cancer”[All Fields]) Translations laryngeal cancer: “laryngeal neoplasms”[MeSH Terms] OR (“laryngeal”[All Fields] AND “neoplasms”[All Fields]) OR “laryngeal neoplasms”[All Fields] OR (“laryngeal”[All Fields] AND “cancer”[All Fields]) OR “laryngeal cancer”[All Fields] | 7 | |
miR-31 AND oropharynx | Search: miR-31 AND oropharynx Sort by: Most Recent “miR-31”[All Fields] AND (“oropharynx”[MeSH Terms] OR “oropharynx”[All Fields] OR “oropharynxes”[All Fields]) Translations oropharynx: “oropharynx”[MeSH Terms] OR “oropharynx”[All Fields] OR “oropharynxes”[All Fields] | 1 | |
Total PubMed | 462 | ||
Duplicates removed (PubMed) EndNote | 432 | ||
SCOPUS | miR-31 AND HNSCC | TITLE-ABS-KEY (mir-31 AND hnscc) | 13 |
miR-31 AND OSCC | TITLE-ABS-KEY (mir-31 AND oscc) | 27 | |
Microrna AND HNSCC AND prognosis | TITLE-ABS-KEY (microrna AND hnscc AND prognosis) | 211 | |
Total SCOPUS | 251 | ||
Duplicates removed (PubMed and SCOPUS) EndNote | 535 | ||
Cochrane library | miR-31 AND HNSCC | miR-31 AND HNSCC in Title Abstract Keyword | 1 |
Microrna AND HNSCC AND prognosis | Microrna AND HNSCC AND prognosis in Title Abstract Keyword | 2 | |
Total Cochrane library | 3 | ||
Total records | 716 | ||
Number of records after duplicates removed (PubMed Scopus and Cochrane library) EndNote | 536 | ||
Number of records after duplicates removed MANUAL | 512 | ||
Other research sources, gray literature, and previous systematic reviews | |||
Google Scholar | Mir 31 | allintitle: “mir 31” | 620 |
http://www.opengrey.eu (accessed on 5 January 2022) DANS EASY Archive | Mir | 80 | |
Previous systematic reviews | 121 | ||
Update of the research completed on 3 March 2022 with the inclusion of records from Web of Science | |||
Web of Science | Head and Neck Cancer | 81,593 | |
Oral cancer | 104,022 | ||
Oral carcinoma | 47,461 | ||
Oral squamous cell carcinoma | 28,540 | ||
Head and Neck Squamous Cell Carcinoma | 38,318 | ||
Pharyngeal cancer | 3766 | ||
miR-31 | 972 | ||
Total Web Of Science | 257,723 | ||
PubMed | Oral carcinoma OR Oral Cancer OR Head and Neck Cancer OR Oral squamous cell carcinoma OR Head and Neck Squamous Cell Carcinoma OR pharyngeal cancer | Search: Oral carcinoma OR Oral Cancer OR Head and Neck Cancer OR Oral squamous cell carcinoma OR Head and Neck Squamous Cell Carcinoma OR pharyngeal cancer ((“mouth”[MeSH Terms] OR “mouth”[All Fields] OR “oral”[All Fields]) AND (“carcinoma”[MeSH Terms] OR “carcinoma”[All Fields] OR “carcinomas”[All Fields] OR “carcinoma s”[All Fields])) OR (“mouth neoplasms”[MeSH Terms] OR (“mouth”[All Fields] AND “neoplasms”[All Fields]) OR “mouth neoplasms”[All Fields] OR (“oral”[All Fields] AND “cancer”[All Fields]) OR “oral cancer”[All Fields]) OR (“head and neck neoplasms”[MeSH Terms] OR (“head”[All Fields] AND “neck”[All Fields] AND “neoplasms”[All Fields]) OR “head and neck neoplasms”[All Fields] OR (“head”[All Fields] AND “neck”[All Fields] AND “cancer”[All Fields]) OR “head and neck cancer”[All Fields]) OR (“squamous cell carcinoma of head and neck”[MeSH Terms] OR (“squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields] AND “head”[All Fields] AND “neck”[All Fields]) OR “squamous cell carcinoma of head and neck”[All Fields] OR (“oral”[All Fields] AND “squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields]) OR “oral squamous cell carcinoma”[All Fields]) OR (“squamous cell carcinoma of head and neck”[MeSH Terms] OR (“squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields] AND “head”[All Fields] AND “neck”[All Fields]) OR “squamous cell carcinoma of head and neck”[All Fields] OR (“head”[All Fields] AND “neck”[All Fields] AND “squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields]) OR “head and neck squamous cell carcinoma”[All Fields]) OR (“pharyngeal neoplasms”[MeSH Terms] OR (“pharyngeal”[All Fields] AND “neoplasms”[All Fields]) OR “pharyngeal neoplasms”[All Fields] OR (“pharyngeal”[All Fields] AND “cancer”[All Fields]) OR “pharyngeal cancer”[All Fields]) Translations Oral: “mouth”[MeSH Terms] OR “mouth”[All Fields] OR “oral”[All Fields] carcinoma: “carcinoma”[MeSH Terms] OR “carcinoma”[All Fields] OR “carcinomas”[All Fields] OR “carcinoma’s”[All Fields] Oral Cancer: “mouth neoplasms”[MeSH Terms] OR (“mouth”[All Fields] AND “neoplasms”[All Fields]) OR “mouth neoplasms”[All Fields] OR (“oral”[All Fields] AND “cancer”[All Fields]) OR “oral cancer”[All Fields] Head and Neck Cancer: “head and neck neoplasms”[MeSH Terms] OR (“head”[All Fields] AND “neck”[All Fields] AND “neoplasms”[All Fields]) OR “head and neck neoplasms”[All Fields] OR (“head”[All Fields] AND “neck”[All Fields] AND “cancer”[All Fields]) OR “head and neck cancer”[All Fields] Oral squamous cell carcinoma: “squamous cell carcinoma of head and neck”[MeSH Terms] OR (“squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields] AND “head”[All Fields] AND “neck”[All Fields]) OR “squamous cell carcinoma of head and neck”[All Fields] OR (“oral”[All Fields] AND “squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields]) OR “oral squamous cell carcinoma”[All Fields] Head and Neck Squamous Cell Carcinoma: “squamous cell carcinoma of head and neck”[MeSH Terms] OR (“squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields] AND “head”[All Fields] AND “neck”[All Fields]) OR “squamous cell carcinoma of head and neck”[All Fields] OR (“head”[All Fields] AND “neck”[All Fields] AND “squamous”[All Fields] AND “cell”[All Fields] AND “carcinoma”[All Fields]) OR “head and neck squamous cell carcinoma”[All Fields] pharyngeal cancer: “pharyngeal neoplasms”[MeSH Terms] OR (“pharyngeal”[All Fields] AND “neoplasms”[All Fields]) OR “pharyngeal neoplasms”[All Fields] OR (“pharyngeal”[All Fields] AND “cancer”[All Fields]) OR “pharyngeal cancer”[All Fields] | 445,203 |
Scopus | TITLE-ABS-KEY (“Oral carcinoma” OR “Oral Cancer” OR “Head and Neck Cancer” OR “Oral squamous cell carcinoma” OR “Head and Neck Squamous Cell Carcinoma” OR “pharyngeal cancer”) | 97,781 | |
Total of updated records | 542,984 |
First Author, Data | Country | Study Design | Number of Patients | Follow-Up Max | Tumor Type\Tumor Site | Cut-off | miR | HR miR-31 Low and High Expression (OS, PFS, CSS, DFS, RFS) |
---|---|---|---|---|---|---|---|---|
Jakob (2019) [33] | Germany | RT | 36 | 60 months | OSCC | median | miR-21, miR-29, miR-31, miR-99a, miR-99b, miR-100, miR-143, miR-155. | OS:HR 3.69 (1.07–12.79) p = 0.028 RFS:HR 1.82(0.66–5.05) p = 2.4297 PFS: HR 2.31 (0.94–5.69) p = 0.05982 |
Wang (2018) [34] | China | RT | 118 | 60 months | HNSCC | median | miR-31 | OS: HR 3.31 (1.42–5.36) * p = 0.015 DFS: HR 3.86 (1.53–6.05) p = 0.009 |
Qiang (2019) [29] | China | RT | 46 | 60 months | 21 HSCC, 25 LSCC | median | miR-31 | OS: HR 1.38 (1.02–1.87) p = 0.036 |
Tu (2021) [30] | Taiwan | RT | 40 | 160 months | OSCC | median | miR-31 | OS: HR 1.68 (0.7747–3.6433) p = 0.189 |
Chen (2018) [36] 1 | China | RT | 509 (307 con R) | 80 months | HNSCC | median | miR-99a, miR-31 miR-410, miR-424, miR-495 | OS R: HR 3.65, (2.46–8.16) p < 0.0001; OS: HR 1.81 (1.45–2.57) p < 0.0001 |
Gao (2013) [35] 2 | USA | RT | 150 | 50 months | OPSCC | median | miR-9, miR-223, miR-31, miR-18a, miR-155 | OS HR 3.22 p = 0.0022 |
Hung (2016) [37] 3 | Taiwan | Prospective | 46 | 28 months | OPMD | median | miR-21, miR-31 | PFS:HR 8.43 (1.04–68.03) p = 0.047 |
First Author, Data | Sample | Clinical Data | Marker Quantification | Prognostication | Statistics | Classical Prognostic Factors | Score |
---|---|---|---|---|---|---|---|
Wang (2018) [34] | 3 | 2 | 3 | 2 | 2 | 3 | 15 |
Qiang (2019) [29] | 2 | 3 | 3 | 2 | 2 | 2 | 14 |
Tu (2021) [30] | 1 | 3 | 3 | 2 | 2 | 2 | 13 |
Jakob (2019) [33] | 1 | 3 | 3 | 3 | 3 | 3 | 16 |
Certainty Assessment | No. of Patients | Effect | Certainty | |||||||
---|---|---|---|---|---|---|---|---|---|---|
No. of Studies | Study Design | Risk of Bias | Inconsistency | Indirectness | Imprecision | Other Considerations | Relative (95% CI) | Absolute (95% CI) | ||
4 | observational studies | not serious | not serious | not serious | serious 1 | strong association | 240 | HR 1.58 (1.21 to 2.06) | 2 fewer per 1.000 (From 2 fewer to 1 fewer) | ⊕⊕◯◯ Low |
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Dioguardi, M.; Spirito, F.; Sovereto, D.; Alovisi, M.; Aiuto, R.; Garcovich, D.; Crincoli, V.; Laino, L.; Cazzolla, A.P.; Caloro, G.A.; et al. The Prognostic Role of miR-31 in Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-Analysis with Trial Sequential Analysis. Int. J. Environ. Res. Public Health 2022, 19, 5334. https://doi.org/10.3390/ijerph19095334
Dioguardi M, Spirito F, Sovereto D, Alovisi M, Aiuto R, Garcovich D, Crincoli V, Laino L, Cazzolla AP, Caloro GA, et al. The Prognostic Role of miR-31 in Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-Analysis with Trial Sequential Analysis. International Journal of Environmental Research and Public Health. 2022; 19(9):5334. https://doi.org/10.3390/ijerph19095334
Chicago/Turabian StyleDioguardi, Mario, Francesca Spirito, Diego Sovereto, Mario Alovisi, Riccardo Aiuto, Daniele Garcovich, Vito Crincoli, Luigi Laino, Angela Pia Cazzolla, Giorgia Apollonia Caloro, and et al. 2022. "The Prognostic Role of miR-31 in Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-Analysis with Trial Sequential Analysis" International Journal of Environmental Research and Public Health 19, no. 9: 5334. https://doi.org/10.3390/ijerph19095334