Next Article in Journal
Prevalence, Related Factors, and Levels of Burnout Syndrome Among Nurses Working in Gynecology and Obstetrics Services: A Systematic Review and Meta-Analysis
Next Article in Special Issue
The Role of DPP-4 Inhibitors in the Treatment Algorithm of Type 2 Diabetes Mellitus: When to Select, What to Expect
Previous Article in Journal
Anthropometric Indices and Some Aspects of Physical Fitness in Croatian Adolescents by Gender
Previous Article in Special Issue
Chronic Viral Hepatitis Signifies the Association of Premixed Insulin Analogues with Liver Cancer Risks: A Nationwide Population-Based Study
Open AccessReview

Epidermal Growth Factor is Effective in the Treatment of Diabetic Foot Ulcers: Meta-Analysis and Systematic Review

1
Department of Preventive Medicine, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary
2
Department of Internal Medicine, Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh city 70000, Vietnam
3
Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary
4
Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary
5
Department of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
6
Heim Pál National Institute of Pediatrics, 1089 Budapest, Hungary
7
Division of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, 7624 Pécs, Hungary
8
Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, 4028 Debrecen, Hungary
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(14), 2584; https://doi.org/10.3390/ijerph16142584
Received: 28 June 2019 / Revised: 17 July 2019 / Accepted: 18 July 2019 / Published: 19 July 2019
Diabetic foot ulcers (DFUs) are one the common complications of diabetes mellitus. Many trials were performed to evaluate the effect of recombinant human epidermal growth factor (rhEGF) in healing DFUs. This meta-analysis was performed to synthesize the evidence of rhEGF treatment in DFUs in comparison to placebo. Databases included for the search were PubMed, EMBASE, the Cochrane Library, Web of Science, EBSCOhost, ScienceDirect, and Scopus (up to January 2019). The outcome of interest was the complete healing rate of DFUs. We performed random effects meta-analysis stratified by the types of administration route (intralesional injection and topical apply) by calculating the odds ratios (OR) and 95% confidence interval (95% CI). A total of six studies involving 530 patients were eligible for analysis. The combined OR (intralesional injection and topical apply) was 4.005 (95% CI: (2.248; 7.135), p < 0.001). The ORs for intralesional injection and topical application were 3.599 (95% CI: (1.213; 10.677), p = 0.021) and 4.176 (95% CI: (2.112; 8.256), p < 0.001), respectively. Statistical heterogeneity might not be important in overall treatment (I2 = 15.17, p = 0.317) and both of the subgroups (I2: 24.56, p = 0.25 and I2: 33.26, p = 0.213, respectively). Our results support the use of rhEGF in the treatment of DFUs. View Full-Text
Keywords: recombinant human epidermal growth factor; placebo; diabetic mellitus; diabetic foot ulcer; meta-analysis recombinant human epidermal growth factor; placebo; diabetic mellitus; diabetic foot ulcer; meta-analysis
Show Figures

Figure 1

MDPI and ACS Style

Bui, T.Q.; Bui, Q.V.P.; Németh, D.; Hegyi, P.; Szakács, Z.; Rumbus, Z.; Tóth, B.; Emri, G.; Párniczky, A.; Sarlós, P.; Varga, O. Epidermal Growth Factor is Effective in the Treatment of Diabetic Foot Ulcers: Meta-Analysis and Systematic Review. Int. J. Environ. Res. Public Health 2019, 16, 2584. https://doi.org/10.3390/ijerph16142584

AMA Style

Bui TQ, Bui QVP, Németh D, Hegyi P, Szakács Z, Rumbus Z, Tóth B, Emri G, Párniczky A, Sarlós P, Varga O. Epidermal Growth Factor is Effective in the Treatment of Diabetic Foot Ulcers: Meta-Analysis and Systematic Review. International Journal of Environmental Research and Public Health. 2019; 16(14):2584. https://doi.org/10.3390/ijerph16142584

Chicago/Turabian Style

Bui, Thien Q.; Bui, Quoc V.P.; Németh, Dávid; Hegyi, Péter; Szakács, Zsolt; Rumbus, Zoltán; Tóth, Barbara; Emri, Gabriella; Párniczky, Andrea; Sarlós, Patricia; Varga, Orsolya. 2019. "Epidermal Growth Factor is Effective in the Treatment of Diabetic Foot Ulcers: Meta-Analysis and Systematic Review" Int. J. Environ. Res. Public Health 16, no. 14: 2584. https://doi.org/10.3390/ijerph16142584

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop