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Article

Prevalence and Factors Associated with Fixed-Dose Combination Antiretroviral Drugs Adherence among HIV-Positive Pregnant Women on Option B Treatment in Mpumalanga Province, South Africa

1
HIV/Aids, STI and TB Unit, Human Sciences Research Council, Private Bag X41, Pretoria 0001, South Africa
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Department of Work & Social Psychology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
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Department of Research and Innovation, University of Limpopo, Sovenga 0727, South Africa
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Miller School of Medicine, University of Miami, 1400 NW 10th Ave, Miami, FL 33136, USA
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(1), 161; https://doi.org/10.3390/ijerph15010161
Received: 30 November 2017 / Revised: 12 January 2018 / Accepted: 19 January 2018 / Published: 20 January 2018
The possibility for all babies to be born and remain HIV-negative for the first year of life is achievable in South Africa. HIV-positive mothers’ adherence to their antiretroviral medication is one of the crucial factors to achieve this target. Cross-sectional data were collected at 12 community health centres, over 12 months (2014–2015), from 673 HIV-positive women, less than 6 months pregnant, attending antenatal care, and on Option B treatment. Adherence measures included the Adults AIDS Clinical Trials Group (AACTG) four-day measure, as well as the Visual Analog Scale (VAS) seven-day measure. Bivariate analyses and multivariate logistic regressions are presented. 78.8% of respondents were adherent on AACTG, while 68.8% reported VAS adherence. Bivariate analyses for increased adherence show significant associations with older age, less/no alcohol usage, disclosure of HIV status, higher HIV knowledge, no desire to avoid ARV side effects, low stigma, and low depression. AACTG showed a negative association with intimate partner violence. Multivariable logistic regression on AACTG and VAS adherence rates resulted in unique contributions to increased adherence of older age, less/no alcohol usage, higher HIV knowledge, lack of depression, and non-disclosure. Programs targeting closer side effect monitoring, HIV disclosure, pre-natal depression, alcohol intake, and HIV knowledge need consideration. View Full-Text
Keywords: HIV/AIDS; pregnant; ARVs; adherence; Option B HIV/AIDS; pregnant; ARVs; adherence; Option B
MDPI and ACS Style

Ramlagan, S.; Peltzer, K.; Ruiter, R.A.C.; Barylski, N.A.; Weiss, S.M.; Sifunda, S. Prevalence and Factors Associated with Fixed-Dose Combination Antiretroviral Drugs Adherence among HIV-Positive Pregnant Women on Option B Treatment in Mpumalanga Province, South Africa. Int. J. Environ. Res. Public Health 2018, 15, 161. https://doi.org/10.3390/ijerph15010161

AMA Style

Ramlagan S, Peltzer K, Ruiter RAC, Barylski NA, Weiss SM, Sifunda S. Prevalence and Factors Associated with Fixed-Dose Combination Antiretroviral Drugs Adherence among HIV-Positive Pregnant Women on Option B Treatment in Mpumalanga Province, South Africa. International Journal of Environmental Research and Public Health. 2018; 15(1):161. https://doi.org/10.3390/ijerph15010161

Chicago/Turabian Style

Ramlagan, Shandir, Karl Peltzer, Robert A.C. Ruiter, Nicole A. Barylski, Stephen M. Weiss, and Sibusiso Sifunda. 2018. "Prevalence and Factors Associated with Fixed-Dose Combination Antiretroviral Drugs Adherence among HIV-Positive Pregnant Women on Option B Treatment in Mpumalanga Province, South Africa" International Journal of Environmental Research and Public Health 15, no. 1: 161. https://doi.org/10.3390/ijerph15010161

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