Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats
AbstractThe systemic toxicity of different combinations of heavy metal mixtures (HMMs) was studied according to equivalent proportions of the eight most common detectable heavy metals found in fish consumption in the Ningbo area of China. The ion mass proportions of Zn, Cu, Mn, Cr, Ni, Cd, Pb, and Hg were 1070.0, 312.6, 173.1, 82.6, 30.0, 13.3, 6.6, and 1.0, respectively. In this study, 10 experimental groups were set as follows: M8 (Pb + Cd + Hg + Ni + Cu + Zn + Mn + Cr); M5 (Pb + Cd + Hg + Ni + Cr); M4A (Pb + Cd + Hg + Ni); M4B (Cu + Zn + Mn + Cr); M3 (Cu + Zn + Mn); Cr; Cu; Zn; Mn; and control. Sprague Dawley (SD) rats were orally treated with a single dose of each group every three days (10 times in total) for 34 days. After Morris water maze test, blood and tissue samples were collected to obtain biochemical, histopathological and western blot analysis. Results show abnormalities could be observed in different treatment groups, the M4B combination had the most significant change compared to all other groups. In conclusion, combination HMMs may have adverse effects on the hematologic, hepatic, renal and neurobehavioral function, and may also disturb electrolyte and lipid balance. Why M4B combination generated much higher toxic effects than any other combination mixtures or individual heavy metal needs to be further evaluated. View Full-Text
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Su, H.; Li, Z.; Fiati Kenston, S.S.; Shi, H.; Wang, Y.; Song, X.; Gu, Y.; Barber, T.; Aldinger, J.; Zou, B.; Ding, M.; Zhao, J.; Lin, X. Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats. Int. J. Environ. Res. Public Health 2017, 14, 1164.
Su H, Li Z, Fiati Kenston SS, Shi H, Wang Y, Song X, Gu Y, Barber T, Aldinger J, Zou B, Ding M, Zhao J, Lin X. Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats. International Journal of Environmental Research and Public Health. 2017; 14(10):1164.Chicago/Turabian Style
Su, Hong; Li, Zhou; Fiati Kenston, Samuel S.; Shi, Hongbo; Wang, Yafei; Song, Xin; Gu, Yuanliang; Barber, Tabatha; Aldinger, Joni; Zou, Baobo; Ding, Min; Zhao, Jinshun; Lin, Xialu. 2017. "Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats." Int. J. Environ. Res. Public Health 14, no. 10: 1164.
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