Int. J. Environ. Res. Public Health 2017, 14(1), 63; https://doi.org/10.3390/ijerph14010063
Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer’s Disease Risk
1
Department of Nursing, Yuanpei University of Medical Technology, No.306, Yuanpei Street, Hsinchu 30015, Taiwan
2
Graduate Institute of Clinical Medical Sciences, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan
3
College of Nursing, Augusta University (Previously Georgia Regents University), 987 St. Sebastian Way, EC 4505, Augusta, GA 30912, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Martin Röösli
Received: 15 November 2016 / Revised: 28 December 2016 / Accepted: 5 January 2017 / Published: 11 January 2017
(This article belongs to the Section Global Health)
Abstract
Background: Alzheimer’s disease (AD) is a significant public health issue. AD has been linked with methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, but the findings have been inconsistent. The purpose of this meta-predictive analysis is to examine the associations between MTHFR polymorphisms and epigenetic factors, including air pollution, with AD risk using big data analytics approaches. Methods and Results: Forty-three studies (44 groups) were identified by searching various databases. MTHFR C677T TT and CT genotypes had significant associations with AD risk in all racial populations (RR = 1.13, p = 0.0047; and RR = 1.12, p < 0.0001 respectively). Meta-predictive analysis showed significant increases of percentages of MTHFR C677T polymorphism with increased air pollution levels in both AD case group and control group (p = 0.0021–0.0457); with higher percentages of TT and CT genotypes in the AD case group than that in the control group with increased air pollution levels. Conclusions: The impact of MTHFR C677T polymorphism on susceptibility to AD was modified by level of air pollution. Future studies are needed to further examine the effects of gene-environment interactions including air pollution on AD risk for world populations. View Full-Text
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Wu, S.-M.; Chen, Z.-F.; Young, L.; Shiao, S.P.K. Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer’s Disease Risk. Int. J. Environ. Res. Public Health 2017, 14, 63.
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