Next Article in Journal
Parks and Green Areas Are Associated with Decreased Risk for Hyperlipidemia
Next Article in Special Issue
Parental Perceptions of the Social Environment Are Inversely Related to Constraint of Adolescents’ Neighborhood Physical Activity
Previous Article in Journal
Association between the Osteoporosis Self-Assessment Tool for Asians Score and Mortality in Patients with Isolated Moderate and Severe Traumatic Brain Injury: A Propensity Score-Matched Analysis
Previous Article in Special Issue
Mediation of the Physical Activity and Healthy Nutrition Behaviors of Preschool Children by Maternal Cognition in China
Open AccessArticle

Antenatal Dexamethasone Exposure in Preterm Infants Is Associated with Allergic Diseases and the Mental Development Index in Children

by Wan-Ning Tseng 1,†, Chih-Cheng Chen 1,†, Hong-Ren Yu 1,2, Li-Tung Huang 1,3,* and Ho-Chang Kuo 1,2,*
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
Department of Traditional Chinese Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Katherine P. Theall and Carolyn C. Johnson
Int. J. Environ. Res. Public Health 2016, 13(12), 1206;
Received: 6 October 2016 / Revised: 16 November 2016 / Accepted: 1 December 2016 / Published: 3 December 2016
(This article belongs to the Special Issue Environmental Influences on Maternal and Child Health)
Background: Antenatal steroid administration may benefit fetal lung maturity in preterm infants. Although some studies have shown that this treatment may increase asthma in childhood, the correlation between antenatal dexamethasone exposure and allergic diseases remains unclear. The purpose of this study is to investigate the association between antenatal dexamethasone and T cell expression in childhood allergic diseases. Methods: We recruited a cohort of preterm infants born at Kaohsiung Chang Gung Memorial Hospital between 2007 and 2010 with a gestational age of less than 35 weeks and body weight at birth of less than 1500 g. The status of antenatal exposure to steroids and allergic diseases were surveyed using a modified ISAAC questionnaire for subjects aged 2–5 years old. We analyzed Th1/Th2/Th17 expression of mRNA, cytokines (using the Magpix® my-system), and mental development index (MDI). Results: Among the 40 patients that were followed, the data showed that the antenatal dexamethasone exposure group (N = 24) had a significantly higher incidence of allergic diseases (75.0% vs. 18.8%, p < 0.0001) when compared to the non-dexamethasone exposure group (N = 16), especially with regard to asthma (41.7% vs. 0.0%, p = 0.003) and allergic rhinitis (58.3% vs. 18.8%, p = 0.013), but not atopic dermatitis. No statistical difference was observed in the mRNA expression levels of total white blood cell count between the dexamethasone exposure and non-exposure groups (p > 0.05). However, the asthma group had higher IL-5 levels (p = 0.009), and the MDI was shown to be significantly higher in the dexamethasone exposure group (90.38 ± 3.31 vs. 79.94 ± 3.58, p = 0.043) while no significant difference was found between the PDI of the two groups. Conclusions: Exposure to antenatal dexamethasone in preterm infants will increase their susceptibility to allergic diseases, particularly asthma and allergic rhinitis. Preterm infants’ exposure to antenatal dexamethasone also results in higher MDI scores. Such increases in allergic diseases may be related to increased IL-5 and IL-10 levels. View Full-Text
Keywords: prenatal; dexamethasone; mental development index (MDI); psychomotor developmental index (PDI); allergy prenatal; dexamethasone; mental development index (MDI); psychomotor developmental index (PDI); allergy
Show Figures

Figure 1

MDPI and ACS Style

Tseng, W.-N.; Chen, C.-C.; Yu, H.-R.; Huang, L.-T.; Kuo, H.-C. Antenatal Dexamethasone Exposure in Preterm Infants Is Associated with Allergic Diseases and the Mental Development Index in Children. Int. J. Environ. Res. Public Health 2016, 13, 1206.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop