Next Article in Journal
The Ecology of Gynecological Care for Women
Next Article in Special Issue
Occupational Risks and Pregnancy and Infant Health Outcomes in Florida Farmworkers
Previous Article in Journal
Associations Between Subjective Symptoms and Serum Immunoglobulin E Levels During Asian Dust Events
Previous Article in Special Issue
Joint Exposure to Chemical and Nonchemical Neurodevelopmental Stressors in U.S. Women of Reproductive Age in NHANES
Open AccessReview

Effects of Air Pollution on the Risk of Congenital Anomalies: A Systematic Review and Meta-Analysis

1
School of Public Health, EHESP, Sorbonne-Paris-Cité, Rennes, Cedex 35043, France
2
Inserm—Unit Research 1085, Research Institute of Environmental and Occupational Health, Rennes, Cedex 35043, France
3
Lorraine University Medical School, Nancy, Cedex 54052, France
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2014, 11(8), 7642-7668; https://doi.org/10.3390/ijerph110807642
Received: 26 May 2014 / Revised: 16 July 2014 / Accepted: 16 July 2014 / Published: 31 July 2014
(This article belongs to the Special Issue Maternal and Child Health)
Congenital anomalies are the main causes of preterm and neonatal mortality and morbidity. We investigated the association between congenital anomalies and mothers’ exposure to air pollution during pregnancy by combining risk estimates for a variety of air pollutants (SO2, NO2, PM10, PM2.5, CO and O3) and anomaly defect outcomes. Seventeen articles were included in the systematic review and thirteen studies were taken into account in the meta-analysis. Combined estimated were calculated separately according to whether the exposure metric was continuous or categorical. Only one significant combination was; NO2 concentrations were significantly associated with coarctation of the aorta (OR = 1.20 per 10 ppb, 95% CI, (1.02, 1.41)). This finding could stem from strong heterogeneity in study designs. Improved exposure assessment methods, in particular more accurate spatial measurements or modeling, standardized definition of cases and of better control of confounders are highly recommended for future congenital anomalies research in this area. View Full-Text
Keywords: meta-analysis; congenital anomalies; exposure; air pollution meta-analysis; congenital anomalies; exposure; air pollution
Show Figures

Figure 1

MDPI and ACS Style

Chen, E.K.-C.; Zmirou-Navier, D.; Padilla, C.; Deguen, S. Effects of Air Pollution on the Risk of Congenital Anomalies: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2014, 11, 7642-7668.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop