Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium
Abstract
:1. Introduction
2. Results and Discussion
2.1. The Identification of New Metabolites from Aspergillus terreus PT06-2 at 10% Salinity
2.2. The Effects of Salt Stress on Production of Secondary Metabolites from Aspergillus terreus PT06-2
2.3. The Bioactivities of Metabolites from Aspergillus terreus PT06-2 in 10% Salinity
3. Experimental Section
3.1. General Experimental Procedures
3.2. Fungal Material
3.3. Fermentation and Extraction
3.4. Purification
3.5. Chemical Transformation of 1 into 2
3.6. X-ray Crystal Structure of 2
3.7. Bioassay
4. Conclusions
Supporting Information
marinedrugs-09-01368-s001.pdfAcknowledgments
- Samples Availability: Available from the authors.
References
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Position | 1 a | 2 | 3 b | |||
---|---|---|---|---|---|---|
δC | δH (J in Hz) | δC | δH (J in Hz) | δC | δH (J in Hz) | |
1 | 119.1, qC | 160.7, qC | 168.7, qC | |||
2 | 140.3, qC | 153.4, qC | 139.0, qC | |||
3 | 122.0, CH | 8.87, d (8.3) | 147.2, qC | 132.6, qC | ||
4 | 134.2, CH | 7.67, t (7.8) | 127.4, CH | 86.0, qC | ||
5 | 124.0, CH | 7.32, t (7.8) | 134.8, CH | 170.9, qC | ||
6 | 128.1, CH | 7.99, d (7.8) | 127.3, CH | 7.79, d (7.9) | 39.1, CH2 | 3.44, s |
7 | 169.1, qC | 126.4, CH | 7.92, t (7.9) | |||
8 | 120.6, qC | 7.61, t (7.9) | ||||
9 | 131.3, qC | 8.16, d (7.9) | ||||
10 | 147.9, CH | |||||
1′ | 130.3, qC | 150.1, CH | 124.8, qC | |||
2′ | 148.8, CH | 9.26, s | 122.5, CH | 8.57, s | 132.6, CH | 6.51, br s |
3′ | 128.2, qC | |||||
4′ | 152.6, CH | 8.78, d (4.2) | 135.0, CH | 8.48, d (4.5) | 154.8, qC | |
5′ | 123.6, CH | 7.45, t “like” (6.0) | 160.7, qC | 7.29, dd (4.5, 7.9) | 115.1, CH | 6.52, br d (8.2) |
6′ | 134.9, CH | 8.27, d (6.0) | 153.4, qC | 7.75, d (7.9) | 129.4, CH | 6.55, d (8.2) |
7′ | 163.7, qC | |||||
1″ | 120.1, qC | 124.4, qC | 122.8, qC | |||
2″ | 128.2, qC | 128.7, qC | 130.1, CH | 7.62, br d (8.2) | ||
3″ | 149.8, qC | 153.5, qC | 116.5, CH | 6.97, br d (8.2) | ||
4″ | 123.5, CH | 7.70, d (7.8) | 121.2, CH | 7.03, d (7.8) | 158.7, qC | |
5″ | 126.7, CH | 7.26, t (7.7) | 130.0, CH | 7.28, t (7.8) | 116.5, CH | 6.97, br d (8.2) |
6″ | 126.3, CH | 7.36, d (8.2) | 120.0, CH | 7.33, d (7.8) | 130.1, CH | 7.62, br d (8.2) |
7″ | 169.2, qC | 165.2, qC | ||||
7″-OMe | 53.0, CH3 | 3.95, s | 52.2, CH3 | 3.65, s | ||
2-NH | 11.96, s | |||||
2″-NH | 9.08, s | |||||
3″-OH | 12.22, s |
Compound | MIC (μM) | |||
---|---|---|---|---|
Enterobacter aerogenes | Pseudomonas aeruginosa | Staphylococcus aureus | Candida albicans | |
1 | >100 | >100 | 63.9 | >100 |
2 | 33.5 | >100 | >100 | >100 |
3 | >100 | >100 | >100 | >100 |
4 | >100 | >100 | 52.4 | >100 |
15 | >100 | >100 | >100 | >100 |
Ciprofloxacinlactate | 1 | 30 | 1 | − |
Ketoconazole | − | − | − | 5 |
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Wang, Y.; Zheng, J.; Liu, P.; Wang, W.; Zhu, W. Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium. Mar. Drugs 2011, 9, 1368-1378. https://doi.org/10.3390/md9081368
Wang Y, Zheng J, Liu P, Wang W, Zhu W. Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium. Marine Drugs. 2011; 9(8):1368-1378. https://doi.org/10.3390/md9081368
Chicago/Turabian StyleWang, Yi, Jinkai Zheng, Peipei Liu, Wei Wang, and Weiming Zhu. 2011. "Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium" Marine Drugs 9, no. 8: 1368-1378. https://doi.org/10.3390/md9081368