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Research Progress in the Biosynthetic Mechanisms of Marine Polyether Toxins

State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(10), 594; https://doi.org/10.3390/md17100594
Received: 26 September 2019 / Revised: 17 October 2019 / Accepted: 18 October 2019 / Published: 22 October 2019
(This article belongs to the Special Issue Toxins as Marine-Based Drug Discovery)
Marine polyether toxins, mainly produced by marine dinoflagellates, are novel, complex, and diverse natural products with extensive toxicological and pharmacological effects. Owing to their harmful effects during outbreaks of marine red tides, as well as their potential value for the development of new drugs, marine polyether toxins have been extensively studied, in terms of toxicology, pharmacology, detection, and analysis, structural identification, as well as their biosynthetic mechanisms. Although the biosynthetic mechanisms of marine polyether toxins are still unclear, certain progress has been made. In this review, research progress and current knowledge on the biosynthetic mechanisms of polyether toxins are summarized, including the mechanisms of carbon skeleton deletion, pendant alkylation, and polyether ring formation, along with providing a summary of mined biosynthesis-related genes. Finally, future research directions and applications of marine polyether toxins are discussed. View Full-Text
Keywords: marine polyether toxins; biosynthetic mechanisms; carbon skeleton deletion; pendant alkylation; polyether ring formation; biosynthesis-related genes marine polyether toxins; biosynthetic mechanisms; carbon skeleton deletion; pendant alkylation; polyether ring formation; biosynthesis-related genes
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Wan, X.; Yao, G.; Liu, Y.; Chen, J.; Jiang, H. Research Progress in the Biosynthetic Mechanisms of Marine Polyether Toxins. Mar. Drugs 2019, 17, 594.

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