Potent Cytotoxic Analogs of Amphidinolides from the Atlantic Octocoral Stragulum bicolor
AbstractAmphidinolides are cytotoxic macrolides produced by symbiotic unicellular microalgae of the genus Amphidinium. Here we describe the identification of four related molecules belonging to this macrolide family isolated from the invertebrate Stragulum bicolor. The new molecules, named amphidinolide PX1-PX3 and stragulin A (1–4), show an unprecedented carbon skeleton whose complete stereochemistry has been determined by spectroscopic and computational methods. Differences in the structures of these molecules modulate their biological activity in a panel of tumor cell lines, but the opened derivative stragulin (4) shows a very potent and specific cytotoxic activity (IC50 0.18 µM) against the aggressive human melanoma cell A2058. View Full-Text
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Nuzzo, G.; Gomes, B.A.; Gallo, C.; Amodeo, P.; Sansone, C.; Pessoa, O.D.L.; Manzo, E.; Vitale, R.M.; Ianora, A.; Santos, E.A.; Costa-Lotufo, L.V.; Fontana, A. Potent Cytotoxic Analogs of Amphidinolides from the Atlantic Octocoral Stragulum bicolor. Mar. Drugs 2019, 17, 58.
Nuzzo G, Gomes BA, Gallo C, Amodeo P, Sansone C, Pessoa ODL, Manzo E, Vitale RM, Ianora A, Santos EA, Costa-Lotufo LV, Fontana A. Potent Cytotoxic Analogs of Amphidinolides from the Atlantic Octocoral Stragulum bicolor. Marine Drugs. 2019; 17(1):58.Chicago/Turabian Style
Nuzzo, Genoveffa; Gomes, Bruno A.; Gallo, Carmela; Amodeo, Pietro; Sansone, Clementina; Pessoa, Otília D.L.; Manzo, Emiliano; Vitale, Rosa M.; Ianora, Adrianna; Santos, Evelyne A.; Costa-Lotufo, Leticia V.; Fontana, Angelo. 2019. "Potent Cytotoxic Analogs of Amphidinolides from the Atlantic Octocoral Stragulum bicolor." Mar. Drugs 17, no. 1: 58.
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