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Mar. Drugs 2018, 16(9), 307; https://doi.org/10.3390/md16090307

α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3

1
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
2
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510006, China
3
State Key Laboratory of Applied Microbiology, Southern China, Guangdong Institute of Microbiology, Guangzhou 510075, China
4
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
*
Authors to whom correspondence should be addressed.
Received: 20 August 2018 / Revised: 27 August 2018 / Accepted: 29 August 2018 / Published: 1 September 2018
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Abstract

Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (36), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the province of Guangdong, China. The structures of compounds 16 were determined by analyzing NMR and HRESIMS data. The absolute configurations of 5 and 6 were assigned by comparing their experimental ECD spectra with those reported for similar compounds in the literature. All isolates were evaluated for their α-glucosidase inhibitory activity, of which compounds 3, 5, 10, and 11 showed strong inhibitory effects with IC50 values in the range of 1.5–4.5 μM. View Full-Text
Keywords: α-glucosidase inhibitors; mangrove endophytic fungus; Aspergillus flavus α-glucosidase inhibitors; mangrove endophytic fungus; Aspergillus flavus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wu, Y.; Chen, Y.; Huang, X.; Pan, Y.; Liu, Z.; Yan, T.; Cao, W.; She, Z. α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3. Mar. Drugs 2018, 16, 307.

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