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Open AccessCommunication

A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp. TJ403-1

1
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2018, 16(4), 110; https://doi.org/10.3390/md16040110
Received: 5 March 2018 / Revised: 23 March 2018 / Accepted: 28 March 2018 / Published: 29 March 2018
Marine-derived fungi are a promising and untapped reservoir for discovering structurally interesting and pharmacologically active natural products. In our efforts to identify novel bioactive compounds from marine-derived fungi, four breviane spiroditerpenoids, including a new compound, brevione O (1), and three known compounds breviones I (2), J (3), and H (4), together with a known diketopiperazine alkaloid brevicompanine G (5), were isolated and identified from an ethyl acetate extract of the fermented rice substrate of the coral-derived fungus Penicillium sp. TJ403-1. The absolute structure of 1 was elucidated by HRESIMS, one- and two-dimensional NMR spectroscopic data, and a comparison of its electronic circular dichroism (ECD) spectrum with the literature. Moreover, we confirmed the absolute configuration of 5 by single-crystal X-ray crystallography. All the isolated compounds were evaluated for isocitrate dehydrogenase 1 (IDH1) inhibitory activity and cytotoxicity, and compound 2 showed significant inhibitory activities against HL-60, A-549, and HEP3B tumor cell lines with IC50 values of 4.92 ± 0.65, 8.60 ± 1.36, and 5.50 ± 0.67 µM, respectively. View Full-Text
Keywords: marine-derived fungi; Penicillium sp. TJ403-1; breviane spiroditerpenoid; IDH1 inhibitory activity; cytotoxicity marine-derived fungi; Penicillium sp. TJ403-1; breviane spiroditerpenoid; IDH1 inhibitory activity; cytotoxicity
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Yang, B.; Sun, W.; Wang, J.; Lin, S.; Li, X.-N.; Zhu, H.; Luo, Z.; Xue, Y.; Hu, Z.; Zhang, Y. A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp. TJ403-1. Mar. Drugs 2018, 16, 110.

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