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Open AccessArticle

Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2018, 16(2), 47;
Received: 6 December 2017 / Revised: 9 January 2018 / Accepted: 29 January 2018 / Published: 31 January 2018
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
Three new compounds, tuberazines A–C (13), and eleven known compounds (414) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa tuberculosa. Compounds 14 are rare marine natural products with a pyrazine moiety, and compound 5 is a tricyclic tryptamine derivative isolated from nature for the first time. The structures of all isolated metabolites were determined by analyzing their IR, Mass, NMR, and UV spectrometric data. The absolute configuration of 1 was confirmed by comparing the trend of experimental electronic circular dichroism (ECD) with calculated ECD spectra. The anti-lymphangiogenic activities of new compounds were evaluated in human lymphatic endothelial cells (LECs). Of these, new compound 3 displayed the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs. View Full-Text
Keywords: pyrazines; alkaloids; Palythoa tuberculosa; anti-lymphangiogenesis pyrazines; alkaloids; Palythoa tuberculosa; anti-lymphangiogenesis
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MDPI and ACS Style

Chen, S.-R.; Wang, S.-W.; Su, C.-J.; Hu, H.-C.; Yang, Y.-L.; Hsieh, C.-T.; Peng, C.-C.; Chang, F.-R.; Cheng, Y.-B. Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa. Mar. Drugs 2018, 16, 47.

AMA Style

Chen S-R, Wang S-W, Su C-J, Hu H-C, Yang Y-L, Hsieh C-T, Peng C-C, Chang F-R, Cheng Y-B. Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa. Marine Drugs. 2018; 16(2):47.

Chicago/Turabian Style

Chen, Shu-Rong; Wang, Shih-Wei; Su, Chien-Jung; Hu, Hao-Chun; Yang, Yu-Liang; Hsieh, Chi-Ting; Peng, Chia-Chi; Chang, Fang-Rong; Cheng, Yuan-Bin. 2018. "Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa" Mar. Drugs 16, no. 2: 47.

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