Next Article in Journal
Combination Treatment of Deep Sea Water and Fucoidan Attenuates High Glucose-Induced Insulin-Resistance in HepG2 Hepatocytes
Next Article in Special Issue
Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276
Previous Article in Journal
Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment
Previous Article in Special Issue
Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Marine Drugs
Volume 16
Issue 2
10.3390/md16020047
marinedrugs-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa

by
Shu-Rong Chen
1,†,
Shih-Wei Wang
1,2,†,
Chien-Jung Su
1,
Hao-Chun Hu
1,
Yu-Liang Yang
1,3,
Chi-Ting Hsieh
3,
Chia-Chi Peng
3,
Fang-Rong Chang
1,4,* and
Yuan-Bin Cheng
1,5,*
1
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan
3
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
4
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
5
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Mar. Drugs 2018, 16(2), 47; https://doi.org/10.3390/md16020047
Submission received: 6 December 2017 / Revised: 9 January 2018 / Accepted: 29 January 2018 / Published: 31 January 2018
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
Browse Figures
Versions Notes

Abstract

Three new compounds, tuberazines A–C (1–3), and eleven known compounds (4–14) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa tuberculosa. Compounds 1–4 are rare marine natural products with a pyrazine moiety, and compound 5 is a tricyclic tryptamine derivative isolated from nature for the first time. The structures of all isolated metabolites were determined by analyzing their IR, Mass, NMR, and UV spectrometric data. The absolute configuration of 1 was confirmed by comparing the trend of experimental electronic circular dichroism (ECD) with calculated ECD spectra. The anti-lymphangiogenic activities of new compounds were evaluated in human lymphatic endothelial cells (LECs). Of these, new compound 3 displayed the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs.
Keywords: pyrazines; alkaloids; Palythoa tuberculosa; anti-lymphangiogenesis pyrazines; alkaloids; Palythoa tuberculosa; anti-lymphangiogenesis
Graphical Abstract

Share and Cite

MDPI and ACS Style

Chen, S.-R.; Wang, S.-W.; Su, C.-J.; Hu, H.-C.; Yang, Y.-L.; Hsieh, C.-T.; Peng, C.-C.; Chang, F.-R.; Cheng, Y.-B. Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa. Mar. Drugs 2018, 16, 47. https://doi.org/10.3390/md16020047

AMA Style

Chen S-R, Wang S-W, Su C-J, Hu H-C, Yang Y-L, Hsieh C-T, Peng C-C, Chang F-R, Cheng Y-B. Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa. Marine Drugs. 2018; 16(2):47. https://doi.org/10.3390/md16020047

Chicago/Turabian Style

Chen, Shu-Rong, Shih-Wei Wang, Chien-Jung Su, Hao-Chun Hu, Yu-Liang Yang, Chi-Ting Hsieh, Chia-Chi Peng, Fang-Rong Chang, and Yuan-Bin Cheng. 2018. "Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa" Marine Drugs 16, no. 2: 47. https://doi.org/10.3390/md16020047

APA Style

Chen, S.-R., Wang, S.-W., Su, C.-J., Hu, H.-C., Yang, Y.-L., Hsieh, C.-T., Peng, C.-C., Chang, F.-R., & Cheng, Y.-B. (2018). Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa. Marine Drugs, 16(2), 47. https://doi.org/10.3390/md16020047

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop