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Mar. Drugs 2017, 15(12), 379; https://doi.org/10.3390/md15120379

Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia

1
Marine Nautral Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 15627, Korea
2
Department of Marine Biotechnology, University of Science and Technology, Daejeon 34113, Korea
*
Author to whom correspondence should be addressed.
Received: 23 October 2017 / Revised: 15 November 2017 / Accepted: 23 November 2017 / Published: 4 December 2017
(This article belongs to the Special Issue Marine Glycosides)
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Abstract

Three new sulfated steroidal glycosides (35), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI50 values down to 0.49 μM) against the K562 human leukemia cell line. View Full-Text
Keywords: Conus pulicarius; steroidal glycoside; cholesterol sulfate; cytotoxicity; leukemia Conus pulicarius; steroidal glycoside; cholesterol sulfate; cytotoxicity; leukemia
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Lee, Y.-J.; Han, S.; Kim, S.H.; Lee, H.-S.; Shin, H.J.; Lee, J.S.; Lee, J. Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia. Mar. Drugs 2017, 15, 379.

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