Next Article in Journal
Antibiofilm Activity of the Brown Alga Halidrys siliquosa against Clinically Relevant Human Pathogens
Previous Article in Journal
1H NMR Spectroscopy and MVA Analysis of Diplodus sargus Eating the Exotic Pest Caulerpa cylindracea
Open AccessArticle

Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)

1
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand
2
Chulabhorn Graduate Institute, Chemical Biology Program, Laksi, Bangkok 10210, Thailand
3
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
4
Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
5
Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok 10400, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2015, 13(6), 3567-3580; https://doi.org/10.3390/md13063567
Received: 5 May 2015 / Revised: 25 May 2015 / Accepted: 26 May 2015 / Published: 5 June 2015
Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity. View Full-Text
Keywords: marine fungi; Talaromyces minioluteus; Penicillium minioluteum; sesquiterpene; drimane; caspase-3; cytotoxic activity; fungal metabolites marine fungi; Talaromyces minioluteus; Penicillium minioluteum; sesquiterpene; drimane; caspase-3; cytotoxic activity; fungal metabolites
Show Figures

Figure 1

MDPI and ACS Style

Ngokpol, S.; Suwakulsiri, W.; Sureram, S.; Lirdprapamongkol, K.; Aree, T.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum). Mar. Drugs 2015, 13, 3567-3580.

Show more citation formats Show less citations formats

Article Access Map

1
Only visits after 24 November 2015 are recorded.
Back to TopTop