Next Article in Journal
In Vitro Antitumor Activity of Stellettin B, a Triterpene from Marine Sponge Jaspis stellifera, on Human Glioblastoma Cancer SF295 Cells
Previous Article in Journal
The Effect of Polyunsaturated Aldehydes on Skeletonema marinoi (Bacillariophyceae): The Involvement of Reactive Oxygen Species and Nitric Oxide
Open AccessArticle

Pseudaboydins A and B: Novel Isobenzofuranone Derivatives from Marine Fungus Pseudallescheria boydii Associated with Starfish Acanthaster planci

1
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
2
Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China
3
Institute of Chinese Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China
4
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2014, 12(7), 4188-4199; https://doi.org/10.3390/md12074188
Received: 4 June 2014 / Revised: 3 July 2014 / Accepted: 3 July 2014 / Published: 14 July 2014
Two novel isobenzofuranone derivatives, pseudaboydins A (1) and B (2), along with five known compounds, including (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-hydroxybenzofuran (3), (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-methoxybenzofuran (4), 3,3′-dihydroxy-5,5′-dimethyldiphenyl ether (5), 3-(3-methoxy-5-methylphenoxy)-5-methylphenol (6) and (−)-regiolone (7), were isolated from the culture broth of the marine fungus, Pseudallescheria boydii, associated with the starfish, Acanthaster planci. Their structures were elucidated primarily based on NMR and MS data. The absolute configurations of 14 were determined by CD spectroscopy and single-crystal X-ray diffraction studies. The cytotoxic and antibacterial activities of 14 were evaluated. Pseudaboydin A (1) showed moderate cytotoxic activity against human nasopharyngeal carcinoma cell line HONE1, human nasopharyngeal carcinoma cell line SUNE1 and human glandular lung cancer cell line GLC82 with IC50 values of 37.1, 46.5 and 87.2 μM, respectively. View Full-Text
Keywords: marine fungus; Pseudallescheria boydii; isobenzofuranone; pseudaboydins; cytotoxicity marine fungus; Pseudallescheria boydii; isobenzofuranone; pseudaboydins; cytotoxicity
Show Figures

Figure 1

MDPI and ACS Style

Lan, W.-J.; Liu, W.; Liang, W.-L.; Xu, Z.; Le, X.; Xu, J.; Lam, C.-K.; Yang, D.-P.; Li, H.-J.; Wang, L.-Y. Pseudaboydins A and B: Novel Isobenzofuranone Derivatives from Marine Fungus Pseudallescheria boydii Associated with Starfish Acanthaster planci. Mar. Drugs 2014, 12, 4188-4199.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop