Lower Urinary Tract Symptoms in Uterine Myoma: A Systematic Review and Meta-Analysis
Abstract
1. Introduction
2. Methods
2.1. Search Strategy and Selection Criteria
2.2. Definition of Lower Urinary Tract Symptoms
2.3. Definition of Overactive Bladder
2.4. Data Abstraction
2.5. Data Analysis
3. Result
3.1. Overview of Enrolled Studies
3.2. Studies on LUTSs in UM Without Hysterectomy
3.3. Studies on LUTSs in UM After Hysterectomy
3.4. Risk Assessment of Bias
3.5. Meta-Analysis
4. Discussion
4.1. Prevalence of LUTSs in UM
4.2. Association with Hysterectomy and Other Interventions
4.3. Impact of UM Characteristics
4.4. Factors Influencing the Prevalence of LUTSs
4.5. LUTSs in Malignant vs. Benign Uterine Tumors
4.6. Emerging Evidence from Recently Published Studies
4.7. Limitations and Future Directions
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Variables | Number of Studies | Coefficient (95% CI) | Prevalence (95% CI) | p-Value | I2 (%) | |
---|---|---|---|---|---|---|
By age | 19 | −0.09 (−0.52, 0.33) | 0.49 (0.26, 0.72) | 0.67 | 99.82 | |
By parity | 6 | 0.58 (−0.69, 1.84) | 0.50 (0.35, 0.65) | 0.37 | 99.17 | |
By BMI | 9 | 0.51 (0.29, 0.73) | 0.63 (0.49, 0.75) | <0.001 | 96.51 | |
WHO regions | European | 10 | Ref | 0.53 (0.42, 0.64) | Ref | 96.57 |
Americas | 8 | 0.15 (−0.45, 0.74) | 0.56 (0.48, 0.64) | 0.62 | ||
Western Pacific | 1 | −5.85 (−7.01, −4.61) | 0.003 (0.003, 0.004) | <0.001 | ||
Eastern Mediterranean | - | - | - | - | ||
South-East Asia | - | - | - | - | ||
African | - | - | - | - | ||
Risk of bias | Low | 17 | Ref | 0.48 (0.24, 0.74) | Ref | 99.81 |
Some concerns | 3 | 0.20 (−2.56, 2.95) | 0.53 (0.23, 0.80) | 0.89 | ||
High | - | - | - | - |
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Tan, L.-H.; Tsai, L.-H. Lower Urinary Tract Symptoms in Uterine Myoma: A Systematic Review and Meta-Analysis. Medicina 2025, 61, 890. https://doi.org/10.3390/medicina61050890
Tan L-H, Tsai L-H. Lower Urinary Tract Symptoms in Uterine Myoma: A Systematic Review and Meta-Analysis. Medicina. 2025; 61(5):890. https://doi.org/10.3390/medicina61050890
Chicago/Turabian StyleTan, Lek-Hong, and Li-Hsien Tsai. 2025. "Lower Urinary Tract Symptoms in Uterine Myoma: A Systematic Review and Meta-Analysis" Medicina 61, no. 5: 890. https://doi.org/10.3390/medicina61050890
APA StyleTan, L.-H., & Tsai, L.-H. (2025). Lower Urinary Tract Symptoms in Uterine Myoma: A Systematic Review and Meta-Analysis. Medicina, 61(5), 890. https://doi.org/10.3390/medicina61050890