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Volume 5
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10.21775/cimb.005.099
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Regulated Assembly of the Mitotic Spindle: A Perspective from Two Ends

by
Lynne Cassimeris
* and
Robert V. Skibbens
Department of Biological Sciences, 111 Research Dr., Lehigh University, Bethlehem, PA 18015, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2003, 5(3), 99-112; https://doi.org/10.21775/cimb.005.099
Submission received: 10 March 2003 / Accepted: 2 May 2003 / Published: 1 July 2003
Versions Notes

Abstract

Chromosome segregration and cell division requires the regulated assembly of the mitotic spindle apparatus. This mitotic spindle is composed of condensed chromosomes attached to a dynamic array of microtubules. The microtubule array is nucleated by centrosomes and organized by associated structural and motor proteins. Mechanical linkages between sister chromatids and microtubules are critical for spindle assembly and chromosome segregation. Defects in either chromosome or centrosome segregation can lead to aneuploidy and are correlated with cancer progression. In this review, we discuss current models of how centrosomes and chromosomes organize the spindle for their equal distribution to each daughter cell.
Keywords: mitotic spindle; chromosome; cell division; chromosomes; microtubules; chromosome segregation; centrosome; aneuploidy; cancer; mitotic mitotic spindle; chromosome; cell division; chromosomes; microtubules; chromosome segregation; centrosome; aneuploidy; cancer; mitotic

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MDPI and ACS Style

Cassimeris, L.; Skibbens, R.V. Regulated Assembly of the Mitotic Spindle: A Perspective from Two Ends. Curr. Issues Mol. Biol. 2003, 5, 99-112. https://doi.org/10.21775/cimb.005.099

AMA Style

Cassimeris L, Skibbens RV. Regulated Assembly of the Mitotic Spindle: A Perspective from Two Ends. Current Issues in Molecular Biology. 2003; 5(3):99-112. https://doi.org/10.21775/cimb.005.099

Chicago/Turabian Style

Cassimeris, Lynne, and Robert V. Skibbens. 2003. "Regulated Assembly of the Mitotic Spindle: A Perspective from Two Ends" Current Issues in Molecular Biology 5, no. 3: 99-112. https://doi.org/10.21775/cimb.005.099

APA Style

Cassimeris, L., & Skibbens, R. V. (2003). Regulated Assembly of the Mitotic Spindle: A Perspective from Two Ends. Current Issues in Molecular Biology, 5(3), 99-112. https://doi.org/10.21775/cimb.005.099

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