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Elucidating Drug-Like Compounds and Potential Mechanisms of Corn Silk (Stigma Maydis) against Obesity: A Network Pharmacology Study

Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Hidayat Hussain
Curr. Issues Mol. Biol. 2021, 43(3), 1906-1936; https://doi.org/10.3390/cimb43030133
Received: 23 September 2021 / Revised: 27 October 2021 / Accepted: 3 November 2021 / Published: 6 November 2021
(This article belongs to the Section Molecular Pharmacology)
Corn silk (Stigma Maydis) has been utilized as an important herb against obesity by Chinese, Korean, and Native Americans, but its phytochemicals and mechanisms(s) against obesity have not been deciphered completely. This study aimed to identify promising bioactive constituents and mechanism of action(s) of corn silk (CS) against obesity via network pharmacology. The compounds from CS were identified using Gas Chromatography Mass Spectrometry (GC-MS) and were confirmed ultimately by Lipinski’s rule via SwissADME. The relationships of the compound-targets or obesity-related targets were confirmed by public bioinformatics. The signaling pathways related to obesity, protein-protein interaction (PPI), and signaling pathways-targets-bioactives (STB) were constructed, visualized, and analyzed by RPackage. Lastly, Molecular Docking Test (MDT) was performed to validate affinity between ligand(s) and protein(s) on key signaling pathway(s). We identified a total of 36 compounds from CS via GC-MS, all accepted by Lipinski’s rule. The number of 36 compounds linked to 154 targets, 85 among 154 targets related directly to obesity-targets (3028 targets). Of the final 85 targets, we showed that the PPI network (79 edges, 357 edges), 12 signaling pathways on a bubble chart, and STB network (67 edges, 239 edges) are considered as therapeutic components. The MDT confirmed that two key activators (β-Amyrone, β-Stigmasterol) bound most stably to PPARA, PPARD, PPARG, FABP3, FABP4, and NR1H3 on the PPAR signaling pathway, also, three key inhibitors (Neotocopherol, Xanthosine, and β-Amyrone) bound most tightly to AKT1, IL6, FGF2, and PHLPP1 on the PI3K-Akt signaling pathway. Overall, we provided promising key signaling pathways, targets, and bioactives of CS against obesity, suggesting crucial pharmacological evidence for further clinical testing. View Full-Text
Keywords: corn silk (Stigma Maydis); obesity; network pharmacology; PPAR signaling pathway; PI3K-Akt signaling pathway corn silk (Stigma Maydis); obesity; network pharmacology; PPAR signaling pathway; PI3K-Akt signaling pathway
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MDPI and ACS Style

Oh, K.-K.; Adnan, M.; Cho, D.-H. Elucidating Drug-Like Compounds and Potential Mechanisms of Corn Silk (Stigma Maydis) against Obesity: A Network Pharmacology Study. Curr. Issues Mol. Biol. 2021, 43, 1906-1936. https://doi.org/10.3390/cimb43030133

AMA Style

Oh K-K, Adnan M, Cho D-H. Elucidating Drug-Like Compounds and Potential Mechanisms of Corn Silk (Stigma Maydis) against Obesity: A Network Pharmacology Study. Current Issues in Molecular Biology. 2021; 43(3):1906-1936. https://doi.org/10.3390/cimb43030133

Chicago/Turabian Style

Oh, Ki-Kwang, Md. Adnan, and Dong-Ha Cho. 2021. "Elucidating Drug-Like Compounds and Potential Mechanisms of Corn Silk (Stigma Maydis) against Obesity: A Network Pharmacology Study" Current Issues in Molecular Biology 43, no. 3: 1906-1936. https://doi.org/10.3390/cimb43030133

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