An Overview of Toxicogenomics

Hisham K. Hamadeh; Rupesh P. Amin; Richard S. Paules; Cynthia A. Afshari

doi:10.21775/cimb.004.045

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5 April 2002

An Overview of Toxicogenomics

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National Institute of Environmental Health Sciences, Intramural Microarray Center, PO Box 12233, MD2-04, 111 Alexander Drive Bldg. 101, Research Triangle Park, NC 27709, USA

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Curr. Issues Mol. Biol.2002, 4(2), 45-56;https://doi.org/10.21775/cimb.004.045

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Abstract

Toxicogenomics is a rapidly developing discipline that promises to aid scientists in understanding the molecular and cellular effects of chemicals in biological systems. This field encompasses global assessment of biological effects using technologies such as DNA microarrays or high throughput NMR and protein expression analysis. This review provides an overview of advancing multiple approaches (genomic, proteomic, metabonomic) that may extend our understanding of toxicology and highlights the importance of coupling such approaches with classical toxicity studies.

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