Next Article in Journal
Unexploited Antineoplastic Effects of Commercially Available Anti-Diabetic Drugs
Previous Article in Journal
Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts
Open AccessArticle

The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats

1
Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, INPRFM, Calzada México-Xochimilco 101, Col San Lorenzo Huipulco 14370, Mexico
2
Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados-Sede Sur. IPN, Calzada de los Tenorios 235, Col Granjas Coapa 14330, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Guy Griebel
Pharmaceuticals 2016, 9(2), 21; https://doi.org/10.3390/ph9020021
Received: 31 December 2015 / Revised: 14 April 2016 / Accepted: 18 April 2016 / Published: 3 May 2016
(This article belongs to the Special Issue Antidepressants: Current Progress and Future Prospects)
The use of a combined therapy with low doses of estrogens plus antidepressants to treat depression associated to perimenopause could be advantageous. However the use of these combinations is controversial due to several factors, including the time of intervention in relation to menopause onset. This paper analyzes whether time post-OVX influences the antidepressant-like action of a combination of ethynyl-estradiol (EE2) and citalopram (CIT) in the forced swim test (FST). Middle-aged (15 months old) female Wistar rats were ovariectomized and after one or three weeks treated with EE2 (1.25, 2.5 or 5.0 µg/rat, s.c.; −48 h) or CIT (1.25, 2.5, 5.0 or 10 mg/kg, i.p./3 injections in 24 h) and tested in the FST. In a second experiment, after one or three weeks of OVX, rats received a combination of an ineffective dose of EE2 (1.25 µg/rat, s.c., −48 h) plus CIT (2.5 mg/kg, i.p./3 injections in 24 h) and subjected to the FST. Finally, the uteri were removed and weighted to obtain an index of the peripheral effects of EE2 administration. EE2 (2.5 or 5.0 µg/rat) reduced immobility after one but not three weeks of OVX. In contrast, no CIT dose reduced immobility at one or three weeks after OVX. When EE2 (1.25 µg/rat) was combined with CIT (2.5 mg/kg) an antidepressant-like effect was observed at one but not three weeks post-OVX. The weight of the uteri augmented when EE2 was administrated three weeks after OVX. The data suggest that the time post-OVX is a crucial factor that contributes to observe the antidepressant-like effect of EE2 alone or in combination with CIT. View Full-Text
Keywords: ethynyl-estradiol; citalopram; forced swim test; post-OVX interval; perimenopause; antidepressant-like effect ethynyl-estradiol; citalopram; forced swim test; post-OVX interval; perimenopause; antidepressant-like effect
Show Figures

Figure 1

MDPI and ACS Style

Vega Rivera, N.M.; Gallardo Tenorio, A.; Fernández-Guasti, A.; Estrada Camarena, E. The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats. Pharmaceuticals 2016, 9, 21.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop