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Pharmaceuticals, Volume 7, Issue 7

2014 July - 5 articles

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Articles (5)

  • Editorial
  • Open Access
2 Citations
9,926 Views
11 Pages

16 July 2014

The fields of molecular biology, immunology and genetics have generated many important developments that advance the understanding of the induction and progression of oncological, cardiological and neurological diseases as well as the identification...

(This article belongs to the Special Issue Radiopharmaceutical Chemistry between Imaging and Radioendotherapy)
  • Review
  • Open Access
71 Citations
16,785 Views
42 Pages

The Medicinal Chemistry of Imidazotetrazine Prodrugs

  • Catherine L. Moody and
  • Richard T. Wheelhouse

10 July 2014

Temozolomide (TMZ) is the standard first line treatment for malignant glioma, reaching “blockbuster” status in 2010, yet it remains the only drug in its class. The main constraints on the clinical effectiveness of TMZ therapy are its requirement for...

(This article belongs to the Special Issue Prodrugs: from Design to Clinic)
  • Article
  • Open Access
344 Citations
23,910 Views
18 Pages

Novel Preclinical and Radiopharmaceutical Aspects of [68Ga]Ga-PSMA-HBED-CC: A New PET Tracer for Imaging of Prostate Cancer

  • Matthias Eder,
  • Oliver Neels,
  • Miriam Müller,
  • Ulrike Bauder-Wüst,
  • Yvonne Remde,
  • Martin Schäfer,
  • Ute Hennrich,
  • Michael Eisenhut,
  • Ali Afshar-Oromieh and
  • Klaus Kopka
  • + 1 author

30 June 2014

The detection of prostate cancer lesions by PET imaging of the prostate-specific membrane antigen (PSMA) has gained highest clinical impact during the last years. 68Ga-labelled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]Ga-PSMA-HBED-CC) represents a successfu...

(This article belongs to the Special Issue Radiopharmaceutical Chemistry between Imaging and Radioendotherapy)
  • Article
  • Open Access
15 Citations
8,641 Views
11 Pages

Correlation between the Serum Pepsinogen I Level and the Symptom Degree in Proton Pump Inhibitor-Users Administered with a Probiotic

  • Muneki Igarashi,
  • Jun Nagano,
  • Ayumi Tsuda,
  • Takayoshi Suzuki,
  • Jun Koike,
  • Tetsufumi Uchida,
  • Masashi Matsushima,
  • Tetsuya Mine and
  • Yasuhiro Koga

25 June 2014

In patients with functional upper gastrointestinal disorders such as gastroesophageal reflux disease and functional dyspepsia, the presence of symptoms is thought to occur in the absence of any organic diseases and the mechanisms behind this remain u...

  • Review
  • Open Access
16 Citations
8,718 Views
14 Pages

Imaging Biomarkers or Biomarker Imaging?

  • Markus Mitterhauser and
  • Wolfgang Wadsak

25 June 2014

Since biomarker imaging is traditionally understood as imaging of molecular probes, we highly recommend to avoid any confusion with the previously defined term “imaging biomarkers” and, therefore, only use “molecular probe imaging (MPI)” in that cont...

(This article belongs to the Special Issue Radiopharmaceutical Chemistry between Imaging and Radioendotherapy)
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Pharmaceuticals - ISSN 1424-8247