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Orexin Receptor Targets for Anti-Relapse Medication Development in Drug Addiction

Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Author to whom correspondence should be addressed.
Pharmaceuticals 2011, 4(6), 804-821;
Received: 2 May 2011 / Revised: 8 June 2011 / Accepted: 8 June 2011 / Published: 14 June 2011
(This article belongs to the Special Issue Drug Abuse Targets)
Drug addiction is a chronic illness characterized by high rates of relapse. Relapse to drug use can be triggered by re-exposure to drug-associated cues, stressful events, or the drug itself after a period of abstinence. Pharmacological intervention to reduce the impact of relapse-instigating factors offers a promising target for addiction treatment. Growing evidence has implicated an important role of the orexin/hypocretin system in drug reward and drug-seeking, including animal models of relapse. Here, we review the evidence for the role of orexins in modulating reward and drug-seeking in animal models of addiction and the potential for orexin receptors as specific targets for anti-relapse medication approaches. View Full-Text
Keywords: addiction; hypocretin; orexin; reinstatement; relapse addiction; hypocretin; orexin; reinstatement; relapse
MDPI and ACS Style

Zhou, L.; Sun, W.-L.; See, R.E. Orexin Receptor Targets for Anti-Relapse Medication Development in Drug Addiction. Pharmaceuticals 2011, 4, 804-821.

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