Oral Cancer Pain Includes Thermal Allodynia That May Be Attenuated by Chronic Alcohol Consumption
Abstract
:1. Introduction
2. Results
2.1. OSCC-Secreted Factors Activate TRPA1 and TRPV1 Channels
2.2. Advanced OSCC Patients Who Do Not Consume Alcohol Experience More Functional Pain
2.3. OSCC Pain Is Attenuated by Alcohol Consumption
2.4. OSCC Patients Experience Thermal Allodynia
2.5. Tobacco
3. Discussion
4. Materials and Methods
4.1. Human OSCC Cell Lines
4.2. Reagents
4.3. Rat Trigeminal Ganglia (TG) Primary Culture
4.4. CGRP Release Assay and iCGRP Radioimmunoassay (RIA)
4.5. Eye-Wipe Testing
4.6. Expanded UCFS Oral Cancer Pain Questionnaire
4.7. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patient | TNM | Nodal Disease | Location | Sex | Age | Race | EtOH | Tobacco |
---|---|---|---|---|---|---|---|---|
1 | T 2 N1 M0 | Yes | Tongue | M | 47 | Non-Hispanic White | Yes | Yes |
2 | T 4 N2 M0 | Yes | BOT & OP | M | 57 | Non-Hispanic White | Yes | Quit |
3 | T2 N1 M0 | Yes | FOM | M | 62 | Non-Hispanic White | Yes | Quit |
4 | T4 N1 M0 | Yes | Buccal Mucosa | M | 44 | Hispanic White | Yes | Yes |
5 | T2N1M0 | Yes | BOT | M | 46 | Hispanic White | Yes | Yes |
6 | T2 N1 M0 | Yes | Max. alveolar ridge, Palate, BOT | M | 53 | Non-Hispanic White | Yes | Yes |
7 | T2 N2 M0 | Yes | Tongue | M | 63 | Non-Hispanic White | Yes | Quit |
8 | T3N0M0 | No | Soft Palate | M | 73 | Hispanic White | Yes | Yes |
9 | T4 N0 M0 | No | Mand. alveolar ridge | M | 58 | Hispanic White | Yes | No |
10 | T2 N0 M0 | No | Tongue | M | 52 | Hispanic White | Yes | No |
11 | T4 N0 M0 | No | Tongue and FOM | F | 81 | Hispanic White | Yes | Quit |
12 | T1 N0 M0 | No | Tongue | F | 49 | Non-Hispanic White | Yes | Yes |
13 | T1 N0 M0 | No | Tongue | M | 62 | Non-Hispanic White | Yes | Yes |
14 | SCC In Situ | No | Tongue | M | 53 | Hispanic White | Yes | Yes |
15 | T2 N0 M0 | No | Buccal Mucosa | M | 67 | Non-Hispanic White | Yes | Quit |
16 | T2 N0 M0 | No | Tongue | F | 79 | Hispanic White | Yes | Quit |
17 | T1 N0 M0 | No | FOM | F | 75 | Non-Hispanic White | Yes | Quit |
18 | TxN1M0 | Yes | Tongue | F | 67 | Non-Hispanic White | No | No |
19 | T1 N2 M0 | Yes | Palate | M | 58 | Non-Hispanic White | No | Yes |
20 | T4 N1 M0 | Yes | Buccal mucosa | F | 81 | Hispanic White | No | No |
21 | T1 N1 M0 | Yes | Tongue | F | 50 | Non-Hispanic White | No | No |
22 | T1 N0 M0 | No | Tongue | F | 42 | Hispanic White | No | No |
23 | T1 N0 M0 | No | Tongue | F | 77 | Hispanic White | No | No |
24 | Invasive SCC | No | Max alveolar ridge | F | 78 | Non-Hispanic White | No | No |
25 | T4 N0 M0 | No | Tongue | M | Hispanic White | No | No | |
26 | T4 N0 M0 | No | Mandible | F | 93 | Non-Hispanic White | No | No |
27 | T2 N0 M0 | No | Tongue | F | 57 | Non-Hispanic White | No | No |
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Gonzales, C.B.; De La Chapa, J.J.; Patwardhan, A.M.; Hargreaves, K.M. Oral Cancer Pain Includes Thermal Allodynia That May Be Attenuated by Chronic Alcohol Consumption. Pharmaceuticals 2023, 16, 518. https://doi.org/10.3390/ph16040518
Gonzales CB, De La Chapa JJ, Patwardhan AM, Hargreaves KM. Oral Cancer Pain Includes Thermal Allodynia That May Be Attenuated by Chronic Alcohol Consumption. Pharmaceuticals. 2023; 16(4):518. https://doi.org/10.3390/ph16040518
Chicago/Turabian StyleGonzales, Cara B., Jorge J. De La Chapa, Amol M. Patwardhan, and Kenneth M. Hargreaves. 2023. "Oral Cancer Pain Includes Thermal Allodynia That May Be Attenuated by Chronic Alcohol Consumption" Pharmaceuticals 16, no. 4: 518. https://doi.org/10.3390/ph16040518