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Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18–30 Years Old): An Independent Post-Marketing Study

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Czech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
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Department of Public Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
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Department of Nursing and Midwifery, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editors: Leonidas A. Phylactou and Alfredo Berzal-Herranz
Pharmaceuticals 2021, 14(10), 1049; https://doi.org/10.3390/ph14101049
Received: 25 August 2021 / Revised: 5 October 2021 / Accepted: 13 October 2021 / Published: 15 October 2021
(This article belongs to the Section Biopharmaceuticals)
Young adults had been widely perceived as a low-risk group for COVID-19 severity; therefore, they were deprioritised within the mass vaccination strategies as their prognosis of COVID-19 infection is relatively more favourable than older age groups. On the other hand, vaccination of this demographic group is indispensable to achieve herd immunity. A cross-sectional survey-based study was used to evaluate the side effects of mRNA-based COVID-19 vaccines among university students in the Czech Republic. The validated questionnaire was delivered in a digital form, and it consisted of demographic data; COVID-19 vaccine-related anamnesis; and local, systemic, orofacial, and skin-related side effects’ prevalence, onset, and duration. Out of the 539 included participants, 70.1% were females and 45.8% were <23 years old. The vast majority (95.2%) reported at least one side effect. The most common side effect was injection site pain (91.8%), followed by fatigue (62.5%), headache (36.4%), and muscle pain (34.9%). The majority of local side effects occurred after both doses (74.4%), while most systemic side effects occurred after the second dose only (56.2%). Most local (94.2%) and systemic (93.3%) side effects resolved within three days after vaccination. Females participants’ adjusted odds ratio (AOR) showed they were 2.566 (CI 95%: 1.103–5.970) times more likely to experience post-vaccination side effects, and the participants who received two doses reported an increased AOR of 1.896 (0.708–5.077) for experiencing side effects. The results of this study imply that mRNA-based COVID-19 vaccines are highly probably safe for young adults, and further studies are required to investigate the role of medical anamnesis, prior COVID-19 infection, and gender in side effects incidence. View Full-Text
Keywords: BNT162 vaccine; COVID-19; Czech Republic; drug-related side effects and adverse reactions; mass vaccination; mRNA-1273 vaccine; phase IV; prevalence; young adult BNT162 vaccine; COVID-19; Czech Republic; drug-related side effects and adverse reactions; mass vaccination; mRNA-1273 vaccine; phase IV; prevalence; young adult
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MDPI and ACS Style

Riad, A.; Pokorná, A.; Klugarová, J.; Antalová, N.; Kantorová, L.; Koščík, M.; Klugar, M. Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18–30 Years Old): An Independent Post-Marketing Study. Pharmaceuticals 2021, 14, 1049. https://doi.org/10.3390/ph14101049

AMA Style

Riad A, Pokorná A, Klugarová J, Antalová N, Kantorová L, Koščík M, Klugar M. Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18–30 Years Old): An Independent Post-Marketing Study. Pharmaceuticals. 2021; 14(10):1049. https://doi.org/10.3390/ph14101049

Chicago/Turabian Style

Riad, Abanoub, Andrea Pokorná, Jitka Klugarová, Natália Antalová, Lucia Kantorová, Michal Koščík, and Miloslav Klugar. 2021. "Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18–30 Years Old): An Independent Post-Marketing Study" Pharmaceuticals 14, no. 10: 1049. https://doi.org/10.3390/ph14101049

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