Diterpenoids from Plectranthus spp. as Potential Chemotherapeutic Agents via Apoptosis
by
Tomasz Śliwiński 1
, Przemysław Sitarek 2, Ewa Skała 2, Vera M. S. Isca 3,4, Ewelina Synowiec 1, Tomasz Kowalczyk 5, Michał Bijak 6 and 
Patrícia Rijo 3,4,*
Tomasz Śliwiński 1, Przemysław Sitarek 2, Ewa Skała 2, Vera M. S. Isca 3,4, Ewelina Synowiec 1, Tomasz Kowalczyk 5, Michał Bijak 6 and Patrícia Rijo 3,4,*
1
Laboratory of Medical Genetics, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland
2
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
3
Center for Research in Biosciences & Health Technologies (CBIOS), Universidade Lusófona de Humanidades e Tecnologias, 1749-024 Lisboa, Portugal
4
Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal
5
Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland
6
Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(6), 123; https://doi.org/10.3390/ph13060123
Received: 13 May 2020 / Revised: 12 June 2020 / Accepted: 13 June 2020 / Published: 16 June 2020
(This article belongs to the Special Issue Bioactive Compounds from Plants and Foods with Pharmaceutical Interest)
Plectranthus spp. is widely known for its medicinal properties and bioactive metabolites. The cytotoxic and genotoxic properties of the four known abietane diterpenoids: 7α-Acetoxy-6β-hydroxyroyleanone (Roy), 6,7-dehydroroyleanone (Deroy), 7β,6β-dihydroxyroyleanone6 (Diroy), and Parvifloron D (Parv), isolated from P. madagascariensis (Roy, DeRoy, and Diroy) and P. ecklonii (Parv) were evaluated. The tested compounds showed cytotoxic effects against the human leukemia cell line CCRF-CEM and the lung adenocarcinoma cell line A549. All tested compounds induced apoptosis by altering the level of pro- and anti-apoptotic genes. The results show that from the tested diterpenoids, Roy and Parv demonstrated the strongest activity in both human cancer cell lines, changing the permeability mitochondrial membrane potential and reactive oxygen species (ROS) levels, and possibly inducing mtDNA or nDNA damage. In conclusion, the abietane diterpenoids tested may be used in the future as potential natural chemotherapeutic agents
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Keywords:
Plectranthus sp.; cytotoxic activity; apoptosis; DNA damage; mitochondrial membrane potential; ROS levels; gene expression
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Śliwiński, T.; Sitarek, P.; Skała, E.; M. S. Isca, V.; Synowiec, E.; Kowalczyk, T.; Bijak, M.; Rijo, P. Diterpenoids from Plectranthus spp. as Potential Chemotherapeutic Agents via Apoptosis. Pharmaceuticals 2020, 13, 123.
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