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Open AccessArticle

Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Leaves and Stems of Uapaca bojeri Bail. (EUPHORBIACEAE), an Endemic Plant of Madagascar

1
Institut Malgache de Recherches Appliquées, B.P. 3833, 101 Antananarivo, Madagascar
2
Dipartimento di Scienze Agrarie, Forestali e Alimentari, Università degli Studi di Torino, 10095 Grugliasco (TO), Italy
3
Organic Chemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 566, Antananarivo 101, Madagascar
4
Ecole Supérieure des Sciences Agronomiques, Université d’Antananarivo, P.O. Box 566, Antananarivo 101, Madagascar
5
Pharmacy Department, Faculty of Medicine, University of Antananarivo, P.O. Box 566, Antananarivo 101, Madagascar
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(4), 71; https://doi.org/10.3390/ph13040071
Received: 16 March 2020 / Revised: 8 April 2020 / Accepted: 16 April 2020 / Published: 17 April 2020
(This article belongs to the Special Issue Medicinal Plants 2020)
Uapaca bojeri is an endemic Malagasy plant used by the local population. This work aimed to evaluate antioxidant, anti-inflammatory, and antidiabetic activities of the methanol extracts of U. bojeri leaves and stems and to report their total phenolic content and the bioactive compound content by HPLC methods. Antioxidant capacity was determined by DPPH and ferric reducing antioxidant power (FRAP) assays. An in vivo carrageenan-induced paw oedema and acetic acid-induced writhing test in mice were used for anti-inflammatory activity evaluation. An oral glucose tolerance test was performed in mice to evaluate antidiabetic activity. The total bioactive compound content of leaves was higher than that of stems. Stem methanol extract inhibited the free radical DPPH more than the leaf methanol extract. Leaf methanol extract inhibited, in a dose-dependent manner, the carrageenan-induced paw oedema more than the stem extract, but their inhibition of the pain symptoms caused an acetic acid-induced decrease similar to the number of writhes in the dose-dependent case. The leaf and stem methanol extracts significantly reduced blood glucose levels after 30 min of glucose loading in mice compared to the control group blood glucose reduction. The presence of several bioactive compounds in U. bojeri contributed to the different biological activities, but isolation and identification of these bioactive molecules are necessary to confirm these pharmacological properties. View Full-Text
Keywords: tapia; endemism; pharmacological studies; HPLC; phytochemical fingerprint tapia; endemism; pharmacological studies; HPLC; phytochemical fingerprint
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MDPI and ACS Style

Razafindrakoto, Z.R.; Donno, D.; Tombozara, N.; Andriamaniraka, H.; Andrianjara, C.; Ramanitrahasimbola, D.; Beccaro, G.L. Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Leaves and Stems of Uapaca bojeri Bail. (EUPHORBIACEAE), an Endemic Plant of Madagascar. Pharmaceuticals 2020, 13, 71.

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